Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
carB_2Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1122 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase.
 
 0.999
carA
Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.
 0.999
argG
Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 
 0.998
argF
Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
 
 0.991
asnB
Asparagine synthetase B.
  
 
 0.988
pyrI
Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase.
  
 
 0.987
lhyD
L-hydantoinase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.983
glnA
Glutamine synthetase.
  
 0.974
purF_2
Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.971
glmS_2
Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
   
 0.953
Your Current Organism:
Methanobrevibacter filiformis
NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3
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