hypB protein (Methanobrevibacter filiformis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hypB

Hydrogenase isoenzymes nickel incorporation protein HypB. (217 aa)

Predicted Functional Partners:

hypA

0.996

hypD

0.969

hypF

0.956

mobB

0.925

hypC

0.917

hoxH_2

0.881

yitD

0.881

KZX10127.1

0.861

hoxH_1

0.858

hycE_1

0.849

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KZX10127.1	hypA	MBFIL_18750	MBFIL_18730	Hypothetical protein.	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.811
KZX10127.1	hypB	MBFIL_18750	MBFIL_18740	Hypothetical protein.	Hydrogenase isoenzymes nickel incorporation protein HypB.	0.861
hoxH_1	hycE_1	MBFIL_02830	MBFIL_03520	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	0.657
hoxH_1	hypA	MBFIL_02830	MBFIL_18730	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.978
hoxH_1	hypB	MBFIL_02830	MBFIL_18740	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes nickel incorporation protein HypB.	0.858
hoxH_1	hypC	MBFIL_02830	MBFIL_03080	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes formation protein HypC.	0.559
hoxH_1	hypD	MBFIL_02830	MBFIL_02210	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase expression/formation protein HypD.	0.842
hoxH_1	hypF	MBFIL_02830	MBFIL_18600	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Carbamoyltransferase HypF.	0.910
hoxH_2	hypA	MBFIL_14350	MBFIL_18730	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.972
hoxH_2	hypB	MBFIL_14350	MBFIL_18740	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes nickel incorporation protein HypB.	0.881
hoxH_2	hypC	MBFIL_14350	MBFIL_03080	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes formation protein HypC.	0.568
hoxH_2	hypD	MBFIL_14350	MBFIL_02210	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase expression/formation protein HypD.	0.917
hoxH_2	hypF	MBFIL_14350	MBFIL_18600	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Carbamoyltransferase HypF.	0.948
hycE_1	hoxH_1	MBFIL_03520	MBFIL_02830	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.657
hycE_1	hypA	MBFIL_03520	MBFIL_18730	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.754
hycE_1	hypB	MBFIL_03520	MBFIL_18740	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	Hydrogenase isoenzymes nickel incorporation protein HypB.	0.849
hycE_1	hypD	MBFIL_03520	MBFIL_02210	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	Hydrogenase expression/formation protein HypD.	0.694
hycE_1	hypF	MBFIL_03520	MBFIL_18600	Formate hydrogenlyase subunit 5 precursor; Belongs to the complex I 49 kDa subunit family.	Carbamoyltransferase HypF.	0.694
hypA	KZX10127.1	MBFIL_18730	MBFIL_18750	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hypothetical protein.	0.811
hypA	hoxH_1	MBFIL_18730	MBFIL_02830	Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	NAD-reducing hydrogenase HoxS subunit beta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.978