padE_2 protein (Methanobrevibacter filiformis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

padE_2

NADH-dependent phenylglyoxylate dehydrogenase subunit gamma. (172 aa)

Predicted Functional Partners:

porD

0.998

porB

0.998

porA

0.997

korB_1

0.981

korA_1

0.976

cooF_2

0.973

ppsA

0.967

cdhC

0.942

pcaF

0.938

pdhD

0.937

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cdhC	cooF_2	MBFIL_17680	MBFIL_18900	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Iron-sulfur protein.	0.895
cdhC	korB_1	MBFIL_17680	MBFIL_02650	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	2-oxoglutarate oxidoreductase subunit KorB.	0.486
cdhC	padE_2	MBFIL_17680	MBFIL_18860	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	NADH-dependent phenylglyoxylate dehydrogenase subunit gamma.	0.942
cdhC	pcaF	MBFIL_17680	MBFIL_01510	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	beta-ketoadipyl-CoA thiolase.	0.463
cdhC	porA	MBFIL_17680	MBFIL_18880	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Pyruvate synthase subunit PorA.	0.942
cdhC	porB	MBFIL_17680	MBFIL_18890	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Pyruvate synthase subunit PorB.	0.899
cdhC	porD	MBFIL_17680	MBFIL_18870	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Pyruvate synthase subunit PorD.	0.942
cooF_2	cdhC	MBFIL_18900	MBFIL_17680	Iron-sulfur protein.	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	0.895
cooF_2	padE_2	MBFIL_18900	MBFIL_18860	Iron-sulfur protein.	NADH-dependent phenylglyoxylate dehydrogenase subunit gamma.	0.973
cooF_2	porA	MBFIL_18900	MBFIL_18880	Iron-sulfur protein.	Pyruvate synthase subunit PorA.	0.999
cooF_2	porB	MBFIL_18900	MBFIL_18890	Iron-sulfur protein.	Pyruvate synthase subunit PorB.	0.999
cooF_2	porD	MBFIL_18900	MBFIL_18870	Iron-sulfur protein.	Pyruvate synthase subunit PorD.	0.987
korA_1	korB_1	MBFIL_02660	MBFIL_02650	2-oxoglutarate oxidoreductase subunit KorA.	2-oxoglutarate oxidoreductase subunit KorB.	0.999
korA_1	padE_2	MBFIL_02660	MBFIL_18860	2-oxoglutarate oxidoreductase subunit KorA.	NADH-dependent phenylglyoxylate dehydrogenase subunit gamma.	0.976
korA_1	pcaF	MBFIL_02660	MBFIL_01510	2-oxoglutarate oxidoreductase subunit KorA.	beta-ketoadipyl-CoA thiolase.	0.941
korA_1	pdhD	MBFIL_02660	MBFIL_03090	2-oxoglutarate oxidoreductase subunit KorA.	Dihydrolipoyl dehydrogenase.	0.942
korA_1	porA	MBFIL_02660	MBFIL_18880	2-oxoglutarate oxidoreductase subunit KorA.	Pyruvate synthase subunit PorA.	0.939
korA_1	porB	MBFIL_02660	MBFIL_18890	2-oxoglutarate oxidoreductase subunit KorA.	Pyruvate synthase subunit PorB.	0.989
korA_1	porD	MBFIL_02660	MBFIL_18870	2-oxoglutarate oxidoreductase subunit KorA.	Pyruvate synthase subunit PorD.	0.976
korA_1	ppsA	MBFIL_02660	MBFIL_07080	2-oxoglutarate oxidoreductase subunit KorA.	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.	0.940