node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LHK_00974 | dacC | LHK_00974 | LHK_00975 | DUF493 domain containing protein; Belongs to the UPF0250 family. | DacC; D-ala-D-ala-carboxypeptidase; Belongs to the peptidase S11 family. | 0.654 |
LHK_00974 | lipA | LHK_00974 | LHK_00972 | DUF493 domain containing protein; Belongs to the UPF0250 family. | LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.721 |
LHK_00974 | lipB | LHK_00974 | LHK_00973 | DUF493 domain containing protein; Belongs to the UPF0250 family. | LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.813 |
LHK_02380 | lipA | LHK_02380 | LHK_00972 | Predicted esterase; Serine hydrolase involved in the detoxification of formaldehyde. | LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.727 |
aceF | gcsP | LHK_00132 | LHK_02722 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.721 |
aceF | gcvH | LHK_00132 | LHK_02723 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.785 |
aceF | lipA | LHK_00132 | LHK_00972 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.526 |
aceF | lipB | LHK_00132 | LHK_00973 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.648 |
aceF | lpdA1 | LHK_00132 | LHK_00131 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | LpdA1; Dihydrolipoamide dehydrogenase. | 0.998 |
aceF | lpdA2 | LHK_00132 | LHK_02413 | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | LpdA2; Dihydrolipoyl dehydrogenase. | 0.999 |
dacC | LHK_00974 | LHK_00975 | LHK_00974 | DacC; D-ala-D-ala-carboxypeptidase; Belongs to the peptidase S11 family. | DUF493 domain containing protein; Belongs to the UPF0250 family. | 0.654 |
dacC | lipA | LHK_00975 | LHK_00972 | DacC; D-ala-D-ala-carboxypeptidase; Belongs to the peptidase S11 family. | LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.660 |
dacC | lipB | LHK_00975 | LHK_00973 | DacC; D-ala-D-ala-carboxypeptidase; Belongs to the peptidase S11 family. | LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.596 |
gcsP | aceF | LHK_02722 | LHK_00132 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.721 |
gcsP | gcvH | LHK_02722 | LHK_02723 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcsP | lipA | LHK_02722 | LHK_00972 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.573 |
gcsP | lipB | LHK_02722 | LHK_00973 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.547 |
gcsP | lpdA1 | LHK_02722 | LHK_00131 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | LpdA1; Dihydrolipoamide dehydrogenase. | 0.979 |
gcsP | lpdA2 | LHK_02722 | LHK_02413 | GcsP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | LpdA2; Dihydrolipoyl dehydrogenase. | 0.953 |
gcvH | aceF | LHK_02723 | LHK_00132 | GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.785 |