node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | ilvA | LHK_00729 | LHK_00976 | GlyA; Serine hydroxymethyltransferase. | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.937 |
glyA | serB | LHK_00729 | LHK_01051 | GlyA; Serine hydroxymethyltransferase. | SerB; Possible serB. | 0.923 |
glyA | trpA | LHK_00729 | LHK_01252 | GlyA; Serine hydroxymethyltransferase. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.937 |
glyA | trpB | LHK_00729 | LHK_01251 | GlyA; Serine hydroxymethyltransferase. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.937 |
glyA | trpB-2 | LHK_00729 | LHK_02546 | GlyA; Serine hydroxymethyltransferase. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.903 |
ilvA | glyA | LHK_00976 | LHK_00729 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | GlyA; Serine hydroxymethyltransferase. | 0.937 |
ilvA | serB | LHK_00976 | LHK_01051 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | SerB; Possible serB. | 0.913 |
ilvA | trpA | LHK_00976 | LHK_01252 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.924 |
ilvA | trpB | LHK_00976 | LHK_01251 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.951 |
ilvA | trpB-2 | LHK_00976 | LHK_02546 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.903 |
ilvA | trpC | LHK_00976 | LHK_01448 | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.455 |
pabA | trpA | LHK_01495 | LHK_01252 | PabA; Anthranilate synthase. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.981 |
pabA | trpB | LHK_01495 | LHK_01251 | PabA; Anthranilate synthase. | TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.972 |
pabA | trpC | LHK_01495 | LHK_01448 | PabA; Anthranilate synthase. | TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.998 |
pabA | trpD | LHK_01495 | LHK_01494 | PabA; Anthranilate synthase. | TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
pabA | trpE | LHK_01495 | LHK_01843 | PabA; Anthranilate synthase. | TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.999 |
pabA | trpF | LHK_01495 | LHK_01250 | PabA; Anthranilate synthase. | TrpF; N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.998 |
serB | glyA | LHK_01051 | LHK_00729 | SerB; Possible serB. | GlyA; Serine hydroxymethyltransferase. | 0.923 |
serB | ilvA | LHK_01051 | LHK_00976 | SerB; Possible serB. | IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.913 |
serB | trpA | LHK_01051 | LHK_01252 | SerB; Possible serB. | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.902 |