node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LHK_00787 | fhs | LHK_00787 | LHK_02277 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.942 |
LHK_00787 | folD | LHK_00787 | LHK_01018 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.430 |
LHK_00787 | gcsT | LHK_00787 | LHK_02724 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GcsT; The glycine cleavage system catalyzes the degradation of glycine. | 0.926 |
LHK_00787 | glyA | LHK_00787 | LHK_00729 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GlyA; Serine hydroxymethyltransferase. | 0.948 |
LHK_00787 | metH | LHK_00787 | LHK_00107 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.939 |
LHK_00787 | pur9 | LHK_00787 | LHK_03208 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pur9; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase). | 0.923 |
LHK_00787 | purN | LHK_00787 | LHK_00507 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.932 |
LHK_00787 | purT | LHK_00787 | LHK_00619 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
fhs | LHK_00787 | LHK_02277 | LHK_00787 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.942 |
fhs | folD | LHK_02277 | LHK_01018 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcsT | LHK_02277 | LHK_02724 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | GcsT; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
fhs | glyA | LHK_02277 | LHK_00729 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | GlyA; Serine hydroxymethyltransferase. | 0.976 |
fhs | metH | LHK_02277 | LHK_00107 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.953 |
fhs | pur7 | LHK_02277 | LHK_03079 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Pur7; Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.854 |
fhs | pur9 | LHK_02277 | LHK_03208 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Pur9; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase). | 0.989 |
fhs | purL | LHK_02277 | LHK_01237 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PurL; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.978 |
fhs | purN | LHK_02277 | LHK_00507 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
fhs | purT | LHK_02277 | LHK_00619 | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
folD | LHK_00787 | LHK_01018 | LHK_00787 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.430 |
folD | fhs | LHK_01018 | LHK_02277 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Fhs; Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.995 |