node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LHK_02269 | LHK_02342 | LHK_02269 | LHK_02342 | Catalytic domain of components of various dehydrogenase complexes. | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | 0.618 |
LHK_02269 | LHK_02849 | LHK_02269 | LHK_02849 | Catalytic domain of components of various dehydrogenase complexes. | Acetyl-CoA hydrolase/transferase. | 0.913 |
LHK_02269 | accC | LHK_02269 | LHK_00600 | Catalytic domain of components of various dehydrogenase complexes. | AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.908 |
LHK_02269 | aceB | LHK_02269 | LHK_00649 | Catalytic domain of components of various dehydrogenase complexes. | AceB; Malate synthase A; Belongs to the malate synthase family. | 0.907 |
LHK_02269 | aceF | LHK_02269 | LHK_00132 | Catalytic domain of components of various dehydrogenase complexes. | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.929 |
LHK_02269 | acsA | LHK_02269 | LHK_01225 | Catalytic domain of components of various dehydrogenase complexes. | AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.904 |
LHK_02269 | ptb | LHK_02269 | LHK_02452 | Catalytic domain of components of various dehydrogenase complexes. | Ptb; Phosphate acetyltransferase. | 0.919 |
LHK_02269 | sucC | LHK_02269 | LHK_02412 | Catalytic domain of components of various dehydrogenase complexes. | SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.942 |
LHK_02269 | sucD | LHK_02269 | LHK_02411 | Catalytic domain of components of various dehydrogenase complexes. | SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.900 |
LHK_02342 | LHK_02269 | LHK_02342 | LHK_02269 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | Catalytic domain of components of various dehydrogenase complexes. | 0.618 |
LHK_02342 | LHK_02849 | LHK_02342 | LHK_02849 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | Acetyl-CoA hydrolase/transferase. | 0.920 |
LHK_02342 | accC | LHK_02342 | LHK_00600 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.803 |
LHK_02342 | aceF | LHK_02342 | LHK_00132 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.790 |
LHK_02342 | acsA | LHK_02342 | LHK_01225 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.426 |
LHK_02342 | sucC | LHK_02342 | LHK_02412 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.991 |
LHK_02342 | sucD | LHK_02342 | LHK_02411 | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.980 |
LHK_02849 | LHK_02269 | LHK_02849 | LHK_02269 | Acetyl-CoA hydrolase/transferase. | Catalytic domain of components of various dehydrogenase complexes. | 0.913 |
LHK_02849 | LHK_02342 | LHK_02849 | LHK_02342 | Acetyl-CoA hydrolase/transferase. | Succinate dehydrogenase and fumarate reductase iron-sulfur protein. | 0.920 |
LHK_02849 | accC | LHK_02849 | LHK_00600 | Acetyl-CoA hydrolase/transferase. | AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.930 |
LHK_02849 | aceB | LHK_02849 | LHK_00649 | Acetyl-CoA hydrolase/transferase. | AceB; Malate synthase A; Belongs to the malate synthase family. | 0.935 |