node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HAPS_0209 | HAPS_0472 | HAPS_0209 | HAPS_0472 | Putative sulphatase; COG:R;COG3083. | Membrane protein; COG:S;COG3092. | 0.758 |
HAPS_0209 | HAPS_1166 | HAPS_0209 | HAPS_1166 | Putative sulphatase; COG:R;COG3083. | yecA family protein; COG:S;COG3079; Belongs to the UPF0149 family. | 0.630 |
HAPS_0209 | lptC | HAPS_0209 | HAPS_0083 | Putative sulphatase; COG:R;COG3083. | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.599 |
HAPS_0209 | nlpI | HAPS_0209 | HAPS_0475 | Putative sulphatase; COG:R;COG3083. | Lipoprotein NlpI, contains TPR repeats; May be involved in cell division. | 0.657 |
HAPS_0209 | rraB | HAPS_0209 | HAPS_2195 | Putative sulphatase; COG:R;COG3083. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.645 |
HAPS_0209 | rseA | HAPS_0209 | HAPS_0719 | Putative sulphatase; COG:R;COG3083. | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | 0.670 |
HAPS_0209 | seqA | HAPS_0209 | HAPS_0384 | Putative sulphatase; COG:R;COG3083. | Negative replication initiation regulator SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.664 |
HAPS_0209 | yihI | HAPS_0209 | HAPS_0484 | Putative sulphatase; COG:R;COG3083. | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.764 |
HAPS_0472 | HAPS_0209 | HAPS_0472 | HAPS_0209 | Membrane protein; COG:S;COG3092. | Putative sulphatase; COG:R;COG3083. | 0.758 |
HAPS_0472 | HAPS_1166 | HAPS_0472 | HAPS_1166 | Membrane protein; COG:S;COG3092. | yecA family protein; COG:S;COG3079; Belongs to the UPF0149 family. | 0.756 |
HAPS_0472 | lptC | HAPS_0472 | HAPS_0083 | Membrane protein; COG:S;COG3092. | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.760 |
HAPS_0472 | nlpI | HAPS_0472 | HAPS_0475 | Membrane protein; COG:S;COG3092. | Lipoprotein NlpI, contains TPR repeats; May be involved in cell division. | 0.766 |
HAPS_0472 | rraB | HAPS_0472 | HAPS_2195 | Membrane protein; COG:S;COG3092. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.772 |
HAPS_0472 | rseA | HAPS_0472 | HAPS_0719 | Membrane protein; COG:S;COG3092. | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | 0.767 |
HAPS_0472 | seqA | HAPS_0472 | HAPS_0384 | Membrane protein; COG:S;COG3092. | Negative replication initiation regulator SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.769 |
HAPS_0472 | yihI | HAPS_0472 | HAPS_0484 | Membrane protein; COG:S;COG3092. | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.774 |
HAPS_0483 | hemN2 | HAPS_0483 | HAPS_0482 | ATP-dependent Lon protease, bacterial type/putative coproporphyrinogen III oxidase. | Coproporphyrinogen III oxidase; COG:H;COG0635; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.795 |
HAPS_0483 | yihI | HAPS_0483 | HAPS_0484 | ATP-dependent Lon protease, bacterial type/putative coproporphyrinogen III oxidase. | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.881 |
HAPS_1166 | HAPS_0209 | HAPS_1166 | HAPS_0209 | yecA family protein; COG:S;COG3079; Belongs to the UPF0149 family. | Putative sulphatase; COG:R;COG3083. | 0.630 |
HAPS_1166 | HAPS_0472 | HAPS_1166 | HAPS_0472 | yecA family protein; COG:S;COG3079; Belongs to the UPF0149 family. | Membrane protein; COG:S;COG3092. | 0.756 |