node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEP69129.1 | CEP69137.1 | 3209 | 3217 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.915 |
CEP69129.1 | adk | 3209 | 2227 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase/UMP-CMP kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.951 |
CEP69129.1 | guaA | 3209 | 3216 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.987 |
CEP69129.1 | guaB | 3209 | 2772 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.824 |
CEP69129.1 | purA | 3209 | 2135 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.428 |
CEP69129.1 | purH | 3209 | 1678 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | AICARFT/IMPCHase bienzyme. | 0.424 |
CEP69129.1 | tilS | 3209 | 2643 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Lysidine-tRNA(Ile) synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.709 |
CEP69129.1 | xpt | 3209 | 1471 | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.962 |
CEP69137.1 | CEP69129.1 | 3217 | 3209 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase/L-type calcium channel beta subunit; Essential for recycling GMP and indirectly, cGMP. | 0.915 |
CEP69137.1 | ade | 3217 | 1353 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | 0.934 |
CEP69137.1 | adk | 3217 | 2227 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase/UMP-CMP kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.933 |
CEP69137.1 | ftsH | 3217 | 2644 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Peptidase, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.942 |
CEP69137.1 | guaA | 3217 | 3216 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.984 |
CEP69137.1 | guaB | 3217 | 2772 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.940 |
CEP69137.1 | purA | 3217 | 2135 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.929 |
CEP69137.1 | purH | 3217 | 1678 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | AICARFT/IMPCHase bienzyme. | 0.920 |
CEP69137.1 | tilS | 3217 | 2643 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Lysidine-tRNA(Ile) synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.984 |
CEP69137.1 | xpt | 3217 | 1471 | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.880 |
ade | CEP69137.1 | 1353 | 3217 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | Hypoxanthine phosphoribosyl transferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
ade | guaA | 1353 | 3216 | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.603 |