node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEP67362.1 | CEP67363.1 | 1451 | 1452 | Single hybrid motif. | Thiamin diphosphate-binding fold. | 0.999 |
CEP67362.1 | CEP69142.1 | 1451 | 3222 | Single hybrid motif. | Single hybrid motif. | 0.414 |
CEP67362.1 | CEP69468.1 | 1451 | 3548 | Single hybrid motif. | Glycine cleavage T-protein, N-terminal; Belongs to the GcvT family. | 0.812 |
CEP67362.1 | gcvH | 1451 | 1552 | Single hybrid motif. | Glycine cleavage H-protein, subgroup; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.870 |
CEP67362.1 | gcvPA | 1451 | 1551 | Single hybrid motif. | Pyridoxal phosphate-dependent transferase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.610 |
CEP67362.1 | gcvPB | 1451 | 1550 | Single hybrid motif. | Pyridoxal phosphate-dependent transferase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.652 |
CEP67362.1 | glyA | 1451 | 2057 | Single hybrid motif. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.618 |
CEP67362.1 | prs | 1451 | 2602 | Single hybrid motif. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.950 |
CEP67363.1 | CEP67362.1 | 1452 | 1451 | Thiamin diphosphate-binding fold. | Single hybrid motif. | 0.999 |
CEP67363.1 | CEP68250.1 | 1452 | 2453 | Thiamin diphosphate-binding fold. | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | 0.445 |
CEP67363.1 | CEP69142.1 | 1452 | 3222 | Thiamin diphosphate-binding fold. | Single hybrid motif. | 0.998 |
CEP67363.1 | CEP69468.1 | 1452 | 3548 | Thiamin diphosphate-binding fold. | Glycine cleavage T-protein, N-terminal; Belongs to the GcvT family. | 0.756 |
CEP67363.1 | gcvH | 1452 | 1552 | Thiamin diphosphate-binding fold. | Glycine cleavage H-protein, subgroup; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.810 |
CEP67363.1 | prs | 1452 | 2602 | Thiamin diphosphate-binding fold. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.977 |
CEP68250.1 | CEP67363.1 | 2453 | 1452 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Thiamin diphosphate-binding fold. | 0.445 |
CEP68250.1 | CEP69468.1 | 2453 | 3548 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Glycine cleavage T-protein, N-terminal; Belongs to the GcvT family. | 0.757 |
CEP68250.1 | folD | 2453 | 117 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.578 |
CEP68250.1 | gcvH | 2453 | 1552 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Glycine cleavage H-protein, subgroup; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.611 |
CEP68250.1 | gcvPA | 2453 | 1551 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Pyridoxal phosphate-dependent transferase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.559 |
CEP68250.1 | gcvPB | 2453 | 1550 | D-isomer specific 2-hydroxyacid dehydrogenase,catalytic domain. | Pyridoxal phosphate-dependent transferase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.655 |