BDCG_16915 protein (Blastomyces dermatitidis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BDCG_16915

Uncharacterized protein. (103 aa)

Predicted Functional Partners:

BDCG_16917

0.949

BDCG_16916

0.948

BDCG_08124

0.539

BDCG_01774

0.532

BDCG_05933

0.510

BDCG_07762

0.502

BDCG_01487

0.484

BDCG_07972

0.483

BDCG_07091

0.453

BDCG_01517

0.448

Your Current Organism:

Blastomyces dermatitidis

NCBI taxonomy Id: 559297
Other names: Ajellomyces dermatitidis ER-3, B. dermatitidis ER-3, Blastomyces dermatitidis ER-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDCG_01487	BDCG_01517	C5GCX9	C5GBB0	ATP synthase subunit gamma.	ATP synthase subunit delta, mitochondrial.	0.999
BDCG_01487	BDCG_01774	C5GCX9	C5GBP1	ATP synthase subunit gamma.	ABC transporter.	0.771
BDCG_01487	BDCG_07972	C5GCX9	C5GU00	ATP synthase subunit gamma.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
BDCG_01487	BDCG_16915	C5GCX9	A0A179TYW9	ATP synthase subunit gamma.	Uncharacterized protein.	0.484
BDCG_01487	BDCG_16916	C5GCX9	A0A179TZ44	ATP synthase subunit gamma.	ABC2_membrane domain-containing protein.	0.484
BDCG_01487	BDCG_16917	C5GCX9	A0A179TYZ5	ATP synthase subunit gamma.	Uncharacterized protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.	0.484
BDCG_01517	BDCG_01487	C5GBB0	C5GCX9	ATP synthase subunit delta, mitochondrial.	ATP synthase subunit gamma.	0.999
BDCG_01517	BDCG_01774	C5GBB0	C5GBP1	ATP synthase subunit delta, mitochondrial.	ABC transporter.	0.709
BDCG_01517	BDCG_07762	C5GBB0	C5GTL9	ATP synthase subunit delta, mitochondrial.	Cytochrome c oxidase assembly protein subunit 15.	0.426
BDCG_01517	BDCG_07972	C5GBB0	C5GU00	ATP synthase subunit delta, mitochondrial.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
BDCG_01517	BDCG_16915	C5GBB0	A0A179TYW9	ATP synthase subunit delta, mitochondrial.	Uncharacterized protein.	0.448
BDCG_01517	BDCG_16916	C5GBB0	A0A179TZ44	ATP synthase subunit delta, mitochondrial.	ABC2_membrane domain-containing protein.	0.448
BDCG_01517	BDCG_16917	C5GBB0	A0A179TYZ5	ATP synthase subunit delta, mitochondrial.	Uncharacterized protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.	0.448
BDCG_01774	BDCG_01487	C5GBP1	C5GCX9	ABC transporter.	ATP synthase subunit gamma.	0.771
BDCG_01774	BDCG_01517	C5GBP1	C5GBB0	ABC transporter.	ATP synthase subunit delta, mitochondrial.	0.709
BDCG_01774	BDCG_05933	C5GBP1	C5GPN8	ABC transporter.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.527
BDCG_01774	BDCG_07091	C5GBP1	C5GS38	ABC transporter.	1,4-alpha-glucan-branching enzyme.	0.457
BDCG_01774	BDCG_07762	C5GBP1	C5GTL9	ABC transporter.	Cytochrome c oxidase assembly protein subunit 15.	0.502
BDCG_01774	BDCG_07972	C5GBP1	C5GU00	ABC transporter.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.779
BDCG_01774	BDCG_16915	C5GBP1	A0A179TYW9	ABC transporter.	Uncharacterized protein.	0.532

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0543

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

7 of 31

1.79

3.1

1.25e-08

GO:0009059

Macromolecule biosynthetic process

10 of 237

1.06

1.3

8.41e-08

GO:0006269

DNA replication, synthesis of RNA primer

2 of 3

2.26

1.12

0.0084

GO:0044271

Cellular nitrogen compound biosynthetic process

10 of 328

0.92

0.99

9.88e-07

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 139

1.07

0.96

0.00049

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003887

DNA-directed DNA polymerase activity

4 of 12

1.95

1.92

0.00012

GO:0140097

Catalytic activity, acting on DNA

6 of 88

1.27

1.29

0.00012

GO:0003735

Structural constituent of ribosome

4 of 52

1.32

0.93

0.0053

GO:0008408

3-5 exonuclease activity

2 of 9

1.78

0.68

0.0493

GO:0003676

Nucleic acid binding

8 of 457

0.68

0.49

0.0053

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 96

1.29

1.64

1.82e-06

GO:0030894

Replisome

3 of 12

1.83

1.62

0.00043

GO:0009360

DNA polymerase III complex

2 of 5

2.03

1.29

0.0033

GO:0005840

Ribosome

4 of 57

1.28

1.12

0.00087

GO:1990077

Primosome complex

2 of 8

1.83

1.12

0.0059

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:593

DNA replication, and DNA repair

7 of 40

1.68

2.76

3.12e-08

CL:647

DNA polymerase complex, and Chromosomal replication initiator protein DnaA

4 of 10

2.03

2.38

1.29e-05

CL:650

DNA polymerase complex

2 of 5

2.03

0.92

0.0188

CL:107

Ribosome, and Translational elongation

4 of 68

1.2

0.79

0.0099

CL:186

Ribosome

2 of 10

1.73

0.72

0.0404

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdf03030

DNA replication

5 of 15

1.95

2.91

3.65e-07

sdf03440

Homologous recombination

5 of 21

1.81

2.6

7.66e-07

sdf03430

Mismatch repair

4 of 15

1.86

2.23

1.29e-05

sdf03010

Ribosome

4 of 52

1.32

1.15

0.00086

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009360

DNA polymerase III complex

4 of 8

2.13

2.43

1.39e-05

GOCC:0005840

Ribosome

4 of 50

1.34

1.1

0.0016

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 129

1.1

1.03

0.00028

GOCC:1990077

Primosome complex

2 of 14

1.59

0.73

0.0342

GOCC:0032991

Protein-containing complex

8 of 512

0.63

0.47

0.0033

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

6 of 15

2.03

3.69

5.56e-09

KW-0239

DNA-directed DNA polymerase

3 of 7

2.06

1.69

0.00049

KW-0639

Primosome

2 of 3

2.26

1.26

0.0045

KW-0548

Nucleotidyltransferase

4 of 41

1.42

1.22

0.0010

KW-0689

Ribosomal protein

4 of 54

1.3

1.04

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14579

Helix-hairpin-helix motif

2 of 2

2.43

0.78

0.0375

PF07733

Bacterial DNA polymerase III alpha NTPase domain

2 of 2

2.43

0.78

0.0375

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00481

DNA polymerase alpha chain like domain

2 of 2

2.43

1.14

0.0080

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