BDCG_00060 protein (Blastomyces dermatitidis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BDCG_00060

Uncharacterized protein. (1354 aa)

Predicted Functional Partners:

BDCG_00059

0.895

BDCG_07381

0.630

BDCG_16764

0.628

BDCG_01542

0.550

BDCG_07712

0.545

BDCG_06879

0.508

BDCG_00632

0.494

BDCG_07161

0.493

BDCG_05471

0.485

BDCG_01442

0.472

Your Current Organism:

Blastomyces dermatitidis

NCBI taxonomy Id: 559297
Other names: Ajellomyces dermatitidis ER-3, B. dermatitidis ER-3, Blastomyces dermatitidis ER-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDCG_00059	BDCG_00060	C5G6S5	C5G6S6	F-type H+-transporting ATPase subunit F.	Uncharacterized protein.	0.895
BDCG_00059	BDCG_01442	C5G6S5	A0A179TVE6	F-type H+-transporting ATPase subunit F.	Uncharacterized protein.	0.472
BDCG_00059	BDCG_07381	C5G6S5	A0A179U592	F-type H+-transporting ATPase subunit F.	Serine/threonine protein kinase, variant.	0.630
BDCG_00059	BDCG_16764	C5G6S5	A0A179TYB3	F-type H+-transporting ATPase subunit F.	ANK_REP_REGION domain-containing protein.	0.628
BDCG_00060	BDCG_00059	C5G6S6	C5G6S5	Uncharacterized protein.	F-type H+-transporting ATPase subunit F.	0.895
BDCG_00060	BDCG_00632	C5G6S6	C5G8K0	Uncharacterized protein.	KIX_2 domain-containing protein.	0.494
BDCG_00060	BDCG_01442	C5G6S6	A0A179TVE6	Uncharacterized protein.	Uncharacterized protein.	0.472
BDCG_00060	BDCG_01542	C5G6S6	C5GD01	Uncharacterized protein.	Uncharacterized protein.	0.550
BDCG_00060	BDCG_05471	C5G6S6	C5GK18	Uncharacterized protein.	Uncharacterized protein.	0.485
BDCG_00060	BDCG_06879	C5G6S6	C5GQN0	Uncharacterized protein.	DUF1713 domain-containing protein.	0.508
BDCG_00060	BDCG_07161	C5G6S6	C5GSA8	Uncharacterized protein.	Uncharacterized protein.	0.493
BDCG_00060	BDCG_07381	C5G6S6	A0A179U592	Uncharacterized protein.	Serine/threonine protein kinase, variant.	0.630
BDCG_00060	BDCG_07712	C5G6S6	A0A179U399	Uncharacterized protein.	Uncharacterized protein.	0.545
BDCG_00060	BDCG_16764	C5G6S6	A0A179TYB3	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.628
BDCG_00632	BDCG_00060	C5G8K0	C5G6S6	KIX_2 domain-containing protein.	Uncharacterized protein.	0.494
BDCG_00632	BDCG_07381	C5G8K0	A0A179U592	KIX_2 domain-containing protein.	Serine/threonine protein kinase, variant.	0.606
BDCG_00632	BDCG_16764	C5G8K0	A0A179TYB3	KIX_2 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.568
BDCG_01442	BDCG_00059	A0A179TVE6	C5G6S5	Uncharacterized protein.	F-type H+-transporting ATPase subunit F.	0.472
BDCG_01442	BDCG_00060	A0A179TVE6	C5G6S6	Uncharacterized protein.	Uncharacterized protein.	0.472
BDCG_01542	BDCG_00060	C5GD01	C5G6S6	Uncharacterized protein.	Uncharacterized protein.	0.550

page 1 of 3

Network Stats

number of nodes:

9

number of edges:

15

average node degree:

3.33

avg. local clustering coefficient:

0.917

expected number of edges:

11

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060563

Neuroepithelial cell differentiation

3 of 9

3.07

2.79

2.69e-05

GO:0040036

Regulation of fibroblast growth factor receptor signaling pathway

3 of 31

2.53

2.05

0.00036

GO:0110148

Biomineralization

3 of 49

2.33

1.79

0.00090

GO:0030433

Ubiquitin-dependent ERAD pathway

3 of 72

2.17

1.61

0.0016

GO:0036035

Osteoclast development

2 of 8

2.94

1.53

0.0032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005509

Calcium ion binding

7 of 822

1.48

2.17

3.93e-07

GO:0030145

Manganese ion binding

3 of 59

2.25

1.81

0.00076

GO:0051082

Unfolded protein binding

3 of 117

1.96

1.48

0.0022

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 927

1.18

0.68

0.0288

GO:0016301

Kinase activity

4 of 1004

1.15

0.65

0.0343

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

4 of 89

2.2

2.76

9.76e-06

GO:0005794

Golgi apparatus

5 of 1252

1.15

0.9

0.0037

GO:0005635

Nuclear envelope

3 of 296

1.55

0.89

0.0201

GO:0012505

Endomembrane system

8 of 3682

0.88

0.83

5.46e-05

GO:0005789

Endoplasmic reticulum membrane

4 of 958

1.17

0.72

0.0215

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:20628614

(2010) Promoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species.

3 of 4

3.42

3.44

2.52e-06

PMID:33199536

(2020) Mannose-Binding Lectin Possesses Agglutination Activity and Promotes Opsonophagocytosis of Macrophages with Calreticulin Interaction in an Early Vertebrate.

3 of 5

3.32

3.43

2.52e-06

PMID:28254621

(2017) Nutrigenomics and immune function in fish: new insights from omics technologies.

3 of 6

3.25

3.43

2.52e-06

PMID:24060503

(2014) Rainbow trout (Oncorhynchus mykiss) contain two calnexin genes which encode distinct proteins.

3 of 7

3.18

3.42

2.52e-06

PMID:35153391

(2022) Molecular cloning, sequence characterization, and expression analysis of C-type lectin (CTL) and ER-Golgi intermediate compartment 53-kDa protein (ERGIC-53) homologs from the freshwater prawn, Macrobrachium rosenbergii.

3 of 8

3.12

3.41

2.52e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34412

Mixed, incl. FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

4 of 11

3.11

4.65

2.11e-08

CL:39427

Calreticulin, and Protein disulphide isomerase

3 of 6

3.25

3.62

1.22e-06

CL:34416

FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

3 of 6

3.25

3.62

1.22e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04141

Protein processing in endoplasmic reticulum

3 of 179

1.77

1.38

0.0024

onl04145

Phagosome

3 of 210

1.7

1.35

0.0024

onl05168

Herpes simplex virus 1 infection

3 of 342

1.49

1.09

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000480

Scavenging by Class A Receptors

3 of 11

2.98

3.06

9.12e-06

MAP-901042

Calnexin/calreticulin cycle

3 of 33

2.5

2.6

3.85e-05

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

3 of 45

2.37

2.44

6.16e-05

MAP-8957275

Post-translational protein phosphorylation

4 of 168

1.92

2.27

3.85e-05

MAP-381426

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

4 of 199

1.85

2.15

4.99e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005788

Endoplasmic reticulum lumen

4 of 56

2.4

3.24

2.01e-06

GOCC:0012505

Endomembrane system

8 of 2410

1.07

1.21

2.27e-06

GOCC:0005794

Golgi apparatus

4 of 581

1.38

1.01

0.0062

GOCC:0005737

Cytoplasm

8 of 6894

0.61

0.44

0.0062

GOCC:0043231

Intracellular membrane-bounded organelle

8 of 7225

0.59

0.43

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

3 of 26

2.61

2.81

1.82e-05

KW-0256

Endoplasmic reticulum

3 of 108

1.99

1.79

0.00055

KW-0106

Calcium

4 of 429

1.52

1.46

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06702

Golgi casein kinase, C-terminal, Fam20

4 of 6

3.37

5.42

1.34e-09

PF00262

Calreticulin family

3 of 5

3.32

3.68

1.00e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009169

Calreticulin

3 of 3

3.55

3.53

1.84e-06

IPR024869

FAM20

3 of 5

3.32

3.43

2.57e-06

IPR018124

Calreticulin/calnexin, conserved site

3 of 5

3.32

3.43

2.57e-06

IPR009581

FAM20, C-terminal

3 of 5

3.32

3.43

2.57e-06

IPR009033

Calreticulin/calnexin, P domain superfamily

3 of 5

3.32

3.43

2.57e-06

(more ...)

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