BDCG_04365 protein (Blastomyces dermatitidis)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

BDCG_04365

Transcription initiation factor TFIID subunit 6. (496 aa)

Predicted Functional Partners:

BDCG_05878

0.999

BDCG_08230

0.999

BDCG_06608

0.998

BDCG_00698

0.998

BDCG_01548

0.998

BDCG_02736

0.998

BDCG_04039

0.998

BDCG_04932

0.998

BDCG_08010

0.998

BDCG_08646

0.998

Your Current Organism:

Blastomyces dermatitidis

NCBI taxonomy Id: 559297
Other names: Ajellomyces dermatitidis ER-3, B. dermatitidis ER-3, Blastomyces dermatitidis ER-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDCG_00698	BDCG_01548	C5G7B1	C5GD07	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 5.	0.998
BDCG_00698	BDCG_02736	C5G7B1	C5GEL7	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 1.	0.998
BDCG_00698	BDCG_04039	C5G7B1	C5GJ44	TATA-box-binding protein, variant.	Uncharacterized protein.	0.998
BDCG_00698	BDCG_04365	C5G7B1	C5GHX9	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 6.	0.998
BDCG_00698	BDCG_04932	C5G7B1	C5GKA2	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 9B.	0.998
BDCG_00698	BDCG_05878	C5G7B1	C5GPI3	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 12.	0.998
BDCG_00698	BDCG_06608	C5G7B1	A0A179U408	TATA-box-binding protein, variant.	Bromodomain associated protein, variant.	0.995
BDCG_00698	BDCG_08010	C5G7B1	C5GUG1	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 2.	0.998
BDCG_00698	BDCG_08230	C5G7B1	C5GV48	TATA-box-binding protein, variant.	DNA-directed RNA polymerase.	0.994
BDCG_00698	BDCG_08646	C5G7B1	C5GVX2	TATA-box-binding protein, variant.	Transcription initiation factor TFIID subunit 7.	0.998
BDCG_01548	BDCG_00698	C5GD07	C5G7B1	Transcription initiation factor TFIID subunit 5.	TATA-box-binding protein, variant.	0.998
BDCG_01548	BDCG_02736	C5GD07	C5GEL7	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 1.	0.998
BDCG_01548	BDCG_04039	C5GD07	C5GJ44	Transcription initiation factor TFIID subunit 5.	Uncharacterized protein.	0.998
BDCG_01548	BDCG_04365	C5GD07	C5GHX9	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 6.	0.998
BDCG_01548	BDCG_04932	C5GD07	C5GKA2	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 9B.	0.998
BDCG_01548	BDCG_05878	C5GD07	C5GPI3	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 12.	0.998
BDCG_01548	BDCG_06608	C5GD07	A0A179U408	Transcription initiation factor TFIID subunit 5.	Bromodomain associated protein, variant.	0.998
BDCG_01548	BDCG_08010	C5GD07	C5GUG1	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 2.	0.998
BDCG_01548	BDCG_08230	C5GD07	C5GV48	Transcription initiation factor TFIID subunit 5.	DNA-directed RNA polymerase.	0.996
BDCG_01548	BDCG_08646	C5GD07	C5GVX2	Transcription initiation factor TFIID subunit 5.	Transcription initiation factor TFIID subunit 7.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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