node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDR1 | MDR4 | F2SHL1 | P0CU83 | ABC multidrug transporter MDR1; Pleiotropic ABC efflux transporter involved in the modulation susceptibility to fluconazole, voriconazole and miconazole, 3 azoles with similar molecular structure. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.520 |
MDR1 | MFS1 | F2SHL1 | F2SH39 | ABC multidrug transporter MDR1; Pleiotropic ABC efflux transporter involved in the modulation susceptibility to fluconazole, voriconazole and miconazole, 3 azoles with similar molecular structure. | MFS-type efflux pump MFS1; MFS-type efflux pump involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole. Confers also resistance to cycloheximide, suggesting that it acts as a pleiotropic drug transporter with a broad substrate spectrum. | 0.636 |
MDR4 | MDR1 | P0CU83 | F2SHL1 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | ABC multidrug transporter MDR1; Pleiotropic ABC efflux transporter involved in the modulation susceptibility to fluconazole, voriconazole and miconazole, 3 azoles with similar molecular structure. | 0.520 |
MDR4 | MFS1 | P0CU83 | F2SH39 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | MFS-type efflux pump MFS1; MFS-type efflux pump involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole. Confers also resistance to cycloheximide, suggesting that it acts as a pleiotropic drug transporter with a broad substrate spectrum. | 0.652 |
MDR4 | TERG_00588 | P0CU83 | F2SC80 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | Uncharacterized protein. | 0.579 |
MDR4 | TERG_01201 | P0CU83 | F2SFL3 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.474 |
MDR4 | TERG_02410 | P0CU83 | F2SH03 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | I/LWEQ domain-containing protein. | 0.510 |
MDR4 | TERG_03414 | P0CU83 | F2SK61 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | Uncharacterized protein. | 0.560 |
MDR4 | TERG_04224 | P0CU83 | F2SMR6 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | ABC transporter. | 0.492 |
MDR4 | TERG_04442 | P0CU83 | F2SND1 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.482 |
MDR4 | TERG_04770 | P0CU83 | F2SQA6 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | SPX domain-containing protein. | 0.743 |
MDR4 | TERG_06530 | P0CU83 | F2SVF9 | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | Ubiquitin carboxyl-terminal hydrolase. | 0.508 |
MFS1 | MDR1 | F2SH39 | F2SHL1 | MFS-type efflux pump MFS1; MFS-type efflux pump involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole. Confers also resistance to cycloheximide, suggesting that it acts as a pleiotropic drug transporter with a broad substrate spectrum. | ABC multidrug transporter MDR1; Pleiotropic ABC efflux transporter involved in the modulation susceptibility to fluconazole, voriconazole and miconazole, 3 azoles with similar molecular structure. | 0.636 |
MFS1 | MDR4 | F2SH39 | P0CU83 | MFS-type efflux pump MFS1; MFS-type efflux pump involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole. Confers also resistance to cycloheximide, suggesting that it acts as a pleiotropic drug transporter with a broad substrate spectrum. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.652 |
TERG_00588 | MDR4 | F2SC80 | P0CU83 | Uncharacterized protein. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.579 |
TERG_01201 | MDR4 | F2SFL3 | P0CU83 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.474 |
TERG_01201 | TERG_04442 | F2SFL3 | F2SND1 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.987 |
TERG_02410 | MDR4 | F2SH03 | P0CU83 | I/LWEQ domain-containing protein. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.510 |
TERG_03414 | MDR4 | F2SK61 | P0CU83 | Uncharacterized protein. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.560 |
TERG_04224 | MDR4 | F2SMR6 | P0CU83 | ABC transporter. | ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. | 0.492 |