STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MDR4ABC multidrug transporter MDR2; Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds (Probable). Does not acts as an efflux pump for azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole, nor does it modulate susceptibility to cycloheximide. (1366 aa)    
Predicted Functional Partners:
TERG_04770
SPX domain-containing protein.
 
 
 
 0.743
MFS1
MFS-type efflux pump MFS1; MFS-type efflux pump involved in the modulation susceptibility to azoles, including fluconazole, itraconazole, ketoconazole, miconazole and voriconazole. Confers also resistance to cycloheximide, suggesting that it acts as a pleiotropic drug transporter with a broad substrate spectrum.
    
 0.652
TERG_00588
Uncharacterized protein.
   
  
 0.579
TERG_03414
Uncharacterized protein.
   
 0.560
MDR1
ABC multidrug transporter MDR1; Pleiotropic ABC efflux transporter involved in the modulation susceptibility to fluconazole, voriconazole and miconazole, 3 azoles with similar molecular structure.
    
0.520
TERG_02410
I/LWEQ domain-containing protein.
    
 0.510
TERG_06530
Ubiquitin carboxyl-terminal hydrolase.
    
  0.508
TERG_04224
ABC transporter.
    
0.492
TERG_04442
Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.
    
 0.482
TERG_01201
Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.
    
 0.474
Your Current Organism:
Trichophyton rubrum
NCBI taxonomy Id: 559305
Other names: T. rubrum CBS 118892, Trichophyton rubrum CBS 118892
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