SEF17927.1 protein (Jiangella alba) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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Score

SEF17927.1

Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain. (327 aa)

Predicted Functional Partners:

SEF17928.1

0.773

SEE44557.1

0.748

SEF17620.1

0.721

SEE68001.1

0.709

SEF17925.1

0.691

SEF16702.1

0.662

SEE89562.1

0.636

SEF18918.1

0.588

SED62610.1

0.552

SEF17918.1

0.508

Your Current Organism:

Jiangella alba

NCBI taxonomy Id: 561176
Other names: CCTCC AA 208023, DSM 45237, J. alba, JCM 16901, Jiangella alba Qin et al. 2009, Jiangella sp. YIM 61503, YIM 61503

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SED62610.1	SEF17918.1	SAMN04488561_0125	SAMN04488561_6118	AraC-type DNA-binding protein.	AraC-type DNA-binding protein.	0.468
SED62610.1	SEF17927.1	SAMN04488561_0125	SAMN04488561_6123	AraC-type DNA-binding protein.	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain.	0.552
SED62610.1	SEF18918.1	SAMN04488561_0125	SAMN04488561_6989	AraC-type DNA-binding protein.	AraC-type DNA-binding protein.	0.561
SEE44557.1	SEE68001.1	SAMN04488561_1345	SAMN04488561_2241	Transcriptional regulator, AraC family.	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	0.804
SEE44557.1	SEE89562.1	SAMN04488561_1345	SAMN04488561_3225	Transcriptional regulator, AraC family.	AraC-type DNA-binding protein.	0.416
SEE44557.1	SEF17918.1	SAMN04488561_1345	SAMN04488561_6118	Transcriptional regulator, AraC family.	AraC-type DNA-binding protein.	0.703
SEE44557.1	SEF17927.1	SAMN04488561_1345	SAMN04488561_6123	Transcriptional regulator, AraC family.	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain.	0.748
SEE44557.1	SEF18918.1	SAMN04488561_1345	SAMN04488561_6989	Transcriptional regulator, AraC family.	AraC-type DNA-binding protein.	0.754
SEE68001.1	SEE44557.1	SAMN04488561_2241	SAMN04488561_1345	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	Transcriptional regulator, AraC family.	0.804
SEE68001.1	SEE89562.1	SAMN04488561_2241	SAMN04488561_3225	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	AraC-type DNA-binding protein.	0.525
SEE68001.1	SEF16702.1	SAMN04488561_2241	SAMN04488561_5494	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	AraC-type DNA-binding protein.	0.411
SEE68001.1	SEF17620.1	SAMN04488561_2241	SAMN04488561_5964	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	AraC-like ligand binding domain-containing protein.	0.413
SEE68001.1	SEF17918.1	SAMN04488561_2241	SAMN04488561_6118	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	AraC-type DNA-binding protein.	0.406
SEE68001.1	SEF17927.1	SAMN04488561_2241	SAMN04488561_6123	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain.	0.709
SEE68001.1	SEF18918.1	SAMN04488561_2241	SAMN04488561_6989	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	AraC-type DNA-binding protein.	0.410
SEE89562.1	SEE44557.1	SAMN04488561_3225	SAMN04488561_1345	AraC-type DNA-binding protein.	Transcriptional regulator, AraC family.	0.416
SEE89562.1	SEE68001.1	SAMN04488561_3225	SAMN04488561_2241	AraC-type DNA-binding protein.	AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR.	0.525
SEE89562.1	SEF17620.1	SAMN04488561_3225	SAMN04488561_5964	AraC-type DNA-binding protein.	AraC-like ligand binding domain-containing protein.	0.414
SEE89562.1	SEF17918.1	SAMN04488561_3225	SAMN04488561_6118	AraC-type DNA-binding protein.	AraC-type DNA-binding protein.	0.643
SEE89562.1	SEF17927.1	SAMN04488561_3225	SAMN04488561_6123	AraC-type DNA-binding protein.	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain.	0.636

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

29

PPI enrichment p-value:

0.00157

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

4 of 97

1.81

1.79

0.00015

GO:0032787

Monocarboxylic acid metabolic process

7 of 419

1.42

1.75

6.29e-06

GO:0008610

Lipid biosynthetic process

7 of 427

1.41

1.74

6.29e-06

GO:0044255

Cellular lipid metabolic process

7 of 573

1.28

1.51

8.92e-06

GO:0006629

Lipid metabolic process

8 of 782

1.2

1.4

6.29e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

7 of 212

1.71

2.85

2.70e-08

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

4 of 44

2.15

2.5

9.92e-06

GO:0031177

Phosphopantetheine binding

4 of 48

2.11

2.47

1.03e-05

GO:0003824

Catalytic activity

11 of 6088

0.45

0.36

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15389

ChREBP activates metabolic gene expression, and Oxalate--CoA ligase Pcs60-like

5 of 10

2.89

5.13

2.74e-10

CL:15391

Mixed, incl. Acyl transferase domain, and Amino acid adenylation domain

4 of 5

3.1

4.45

7.04e-09

CL:15830

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, and ChREBP activates metabolic gene expression

3 of 119

1.59

1.08

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01100

Metabolic pathways

10 of 4480

0.54

0.42

0.0020

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163765

ChREBP activates metabolic gene expression

7 of 58

2.27

5.38

2.53e-12

MAP-199220

Vitamin B5 (pantothenate) metabolism

7 of 61

2.25

5.34

2.53e-12

MAP-163685

Integration of energy metabolism

7 of 93

2.07

4.6

1.93e-11

MAP-75105

Fatty acyl-CoA biosynthesis

7 of 98

2.05

4.54

2.05e-11

MAP-196849

Metabolism of water-soluble vitamins and cofactors

7 of 161

1.83

3.59

4.41e-10

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14765

Polyketide synthase dehydratase

2 of 11

2.45

0.81

0.0334

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013968

Polyketide synthase, ketoreductase domain

3 of 25

2.27

1.44

0.0020

IPR042104

Polyketide synthase, dehydratase domain superfamily

3 of 33

2.15

1.42

0.0020

IPR020807

Polyketide synthase, dehydratase domain

3 of 32

2.16

1.42

0.0020

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 36

2.11

1.41

0.0020

IPR016039

Thiolase-like

3 of 49

1.98

1.32

0.0027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

3 of 21

2.35

2.04

0.00014

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