STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiHThiazole biosynthesis protein ThiH; KEGG: mac:MA0154 4.9e-20 bioB; biotin synthase K01012; Psort location: Cytoplasmic, score: 8.87. (315 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.998
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.962
thiS
Thiamine biosynthesis protein ThiS.
 
 
  0.937
hydG
Iron-only hydrogenase maturation rSAM protein HydG; KEGG: mac:MA0154 1.2e-17 bioB; biotin synthase K01012; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.892
thiM
Putative hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
  
 0.868
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.840
EEB35181.1
STAS domain protein; KEGG: ava:Ava_0744 6.6e-06 anti-sigma-factor antagonist (STAS) and sugar transfersase K00996; Psort location: Cytoplasmic, score: 8.87.
  
    0.811
EEB35338.1
Stage II sporulation protein E; KEGG: ava:Ava_3723 2.1e-18 response regulator receiver (CheY) modulated serine phosphatase K01079; Psort location: Cytoplasmic, score: 8.87.
   
  
 0.809
EEB35180.1
Hypothetical protein; KEGG: oih:OB0629 2.0e-07 negative regulator of sigma-B activity (switch protein/serine kinase, anti-sigma factor) K04757; Psort location: Cytoplasmic, score: 8.87.
   
    0.809
thiW
Protein ThiW; KEGG: fnu:FN0220 0.0022 autolysin sensor kinase K07704; Psort location: CytoplasmicMembrane, score: 9.99.
       0.781
Your Current Organism:
Anaerococcus hydrogenalis
NCBI taxonomy Id: 561177
Other names: A. hydrogenalis DSM 7454, Anaerococcus hydrogenalis DSM 7454, Anaerococcus hydrogenalis GIFU 7662, Anaerococcus hydrogenalis str. DSM 7454, Anaerococcus hydrogenalis strain DSM 7454
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