STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdkThymidine kinase; KEGG: aha:AHA_1822 1.4e-40 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 8.87. (196 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.926
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.902
EFA22627.1
KEGG: lsa:LSA0801 6.6e-151 pdp; pyrimidine-nucleoside phosphorylase K00756; Psort location: Cytoplasmic, score: 8.87.
    
 0.780
EFA23215.1
Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
       0.778
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.768
deoD
KEGG: lsa:LSA0797 1.7e-65 deoD; purine-nucleoside phosphorylase K03784; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.747
EFA22080.1
Putative haloacid dehalogenase, type II; KEGG: tko:TK0058 3.0e-13 hydrolase, HAD superfamily K01560; Psort location: Cytoplasmic, score: 8.87.
 
  
  0.740
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.716
EFA22742.1
Phosphotransferase system, EIIC; KEGG: blo:BL1632 1.3e-195 ptsG; pts system, glucose-specific IIABC component K02755:K02756:K02757; Psort location: CytoplasmicMembrane, score: 10.00.
      
 0.710
EFA23160.1
Deoxynucleoside kinase; KEGG: san:gbs1867 1.2e-78 similar to deoxypurine kinase subunit K00904; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.644
Your Current Organism:
Bifidobacterium gallicum
NCBI taxonomy Id: 561180
Other names: B. gallicum DSM 20093 = LMG 11596, Bifidobacterium gallicum DSM 20093, Bifidobacterium gallicum DSM 20093 = LMG 11596, Bifidobacterium gallicum JCM 8224, Bifidobacterium gallicum LMG 11596, Bifidobacterium gallicum LMG 11596 = DSM 20093
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