STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)    
Predicted Functional Partners:
EFA23398.1
KEGG: blo:BL0478 2.4e-226 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.987
purH
Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: blo:BL0735 3.7e-212 purH; bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase); IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.961
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
 
 0.952
metF
KEGG: blo:BL0797 6.6e-96 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87.
    
 0.927
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.917
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
     
 0.887
EFA22531.1
KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.814
EFA22034.1
Hypothetical protein; KEGG: blo:BL0478 3.7e-11 fhs; formate--tetrahydrofolate ligase K01938.
  
 
 0.773
EFA23292.1
Lyase; KEGG: blo:BL1800 2.2e-214 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.730
rpsA
30S ribosomal protein S1; KEGG: cno:NT01CX_2096 1.1e-63 RpsA K03527; Psort location: Cytoplasmic, score: 9.98.
  
    0.683
Your Current Organism:
Bifidobacterium gallicum
NCBI taxonomy Id: 561180
Other names: B. gallicum DSM 20093 = LMG 11596, Bifidobacterium gallicum DSM 20093, Bifidobacterium gallicum DSM 20093 = LMG 11596, Bifidobacterium gallicum JCM 8224, Bifidobacterium gallicum LMG 11596, Bifidobacterium gallicum LMG 11596 = DSM 20093
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