STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
CoxICytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (557 aa)    
Predicted Functional Partners:
CoxII
Cytochrome c oxidase subunit 2; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 0.999
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
 0.999
CoxIII
Cytochrome c oxidase subunit 3.
 0.999
FbcB
Ubiquinol-cytochrome c reductase cytochrome b subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
 
 0.995
NuoM
NADH dehydrogenase subunit M.
  
 
 0.978
nuoH
NADH-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
  
 
 0.972
ccoP
Cytochrome c oxidase cbb3-type subunit 3; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
  
 0.971
atpB
ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family.
  
 
 0.953
nuoN
NADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.
 
 
 0.937
FbcF
Ubiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
  
 
 0.929
Your Current Organism:
Mameliella alba
NCBI taxonomy Id: 561184
Other names: Alkalimicrobium pacificum, Alkalimicrobium pacificum Zhang et al. 2015, Antarctobacter sp. JLT354-W, CGMCC 1.12763 [[Alkalimicrobium pacificum]], CGMCC 1.12986 [[Ponticoccus lacteus]], CGMCC 1.7290, JCM 19851 [[Alkalimicrobium pacificum]], JCM 30230 [[Mameliella atlantica]], JCM 30379 [[Ponticoccus lacteus]], KCTC 42178 [[Mameliella phaeodactyli]], LMG 24665, LMG 28107 [[Alkalimicrobium pacificum]], LMG:24665, LMG:28107 [[Alkalimicrobium pacificum]], M. alba, MCCC 1A07531 [[Mameliella atlantica]], MCCC 1A09948 [[Alkalimicrobium pacificum]], MCCC 1K00273 [[Mameliella phaeodactyli]], Mameliella alba Zheng et al. 2010 emend. Liu et al. 2018, Mameliella atlantica, Mameliella atlantica Xu et al. 2015, Mameliella phaeodactyli, Mameliella phaeodactyli Chen et al. 2015, Mameliella sp. L6M1-5, Ponticoccus lacteus, Ponticoccus lacteus Yang et al. 2015, Ponticoccus sp. UMTAT08, Rhodobacteraceae bacterium F15, Rhodobacteraceae bacterium KD53, Roseobacter sp. JL-351, proteobacterium JL351, strain F15 [[Alkalimicrobium pacificum]], strain JL351 [[Ponticoccus lacteus]], strain JLT354-W, strain KD53 [[Mameliella phaeodactyli]], strain L6M1-5 [[Mameliella atlantica]]
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