STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACT07902.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
  
 0.933
ACT07958.1
2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE domain protein; KEGG: eca:ECA1579 2-dehydropantoate 2-reductase.
  
  
  0.925
panC
Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
    
 0.922
ACT07903.1
TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain protein; KEGG: eca:ECA1135 hypothetical protein.
       0.798
ACT08073.1
PFAM: 2OG-Fe(II) oxygenase; KEGG: eca:ECA0909 alkylated DNA repair protein.
   
    0.578
ACT07901.1
PFAM: protein of unknown function DUF520; KEGG: eca:ECA1137 nucleotide-binding protein; Belongs to the UPF0234 family.
       0.573
ACT07056.1
PFAM: protein of unknown function DUF1315; KEGG: eca:ECA2342 hypothetical protein.
  
     0.441
ACT06133.1
PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: spe:Spro_3563 mandelate racemase/muconate lactonizing protein.
   
    0.422
birA
Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
     
 0.401
Your Current Organism:
Dickeya chrysanthemi
NCBI taxonomy Id: 561229
Other names: D. chrysanthemi Ech1591, Dickeya chrysanthemi Ech1591, Dickeya dadantii Ech1591, Dickeya zeae Ech1591
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