Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aaeASecretion protein HlyD family protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (321 aa)    
Predicted Functional Partners:
aaeB
Fusaric acid resistance protein conserved region; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
 
  
 0.965
aaeX
PFAM: protein of unknown function DUF1656; KEGG: eca:ECA0277 hypothetical protein.
 
  
 0.919
PC1_1377
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: pap:PSPA7_2869 outer membrane protein.
 
 
 0.670
slyA
Transcriptional regulator, MarR family; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family.
 
  
 0.664
PC1_3331
TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA3513 multidrug resistance protein B.
  
 
 0.647
PC1_2680
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: eca:ECA2932 putative outer membrane efflux lipoprotein.
 
 
 0.643
macB
ABC transporter related; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
  
 0.607
PC1_1376
PFAM: ABC transporter related; protein of unknown function DUF214; SMART: AAA ATPase; KEGG: mms:mma_1065 macrolide ABC efllux protein; Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
  
  
 0.607
PC1_1070
TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: eca:ECA1170 acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
     0.576
PC1_0992
KEGG: eca:ECA1097 putative type I secretion protein, ATP-binding protein; TIGRFAM: type I secretion system ATPase; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase.
  
 
 0.527
Your Current Organism:
Pectobacterium carotovorum
NCBI taxonomy Id: 561230
Other names: P. carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum str. PC1, Pectobacterium carotovorum subsp. carotovorum strain PC1
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