Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PC1_0909KEGG: eca:ECA0990 hypothetical protein. (203 aa)    
Predicted Functional Partners:
PC1_0908
KEGG: eca:ECA0989 hypothetical protein.
 
 
 0.952
PC1_0910
KEGG: eca:ECA0991 hypothetical protein.
  
  
 0.881
PC1_0911
KEGG: eca:ECA0992 putative prepilin peptidase dependent protein c precursor.
     
 0.878
PC1_2853
PFAM: General secretion pathway protein K; KEGG: eca:ECA3102 general secretion pathway protein K.
  
 
 0.826
recC
Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...]
     
 0.630
PC1_0096
KEGG: eca:ECA4349 hypothetical protein.
  
     0.629
PC1_2516
KEGG: eca:ECA1784 biofilm formation regulatory protein BssS.
  
     0.601
PC1_0913
PFAM: peptidase M16 domain protein; KEGG: eca:ECA0994 protease III precursor; Belongs to the peptidase M16 family.
       0.571
PC1_2049
PFAM: protein of unknown function DUF1283; KEGG: eca:ECA2253 hypothetical protein; Belongs to the UPF0482 family.
  
     0.525
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.522
Your Current Organism:
Pectobacterium carotovorum
NCBI taxonomy Id: 561230
Other names: P. carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum str. PC1, Pectobacterium carotovorum subsp. carotovorum strain PC1
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