node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_2713 | PC1_2745 | PC1_2713 | PC1_2745 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | 0.908 |
PC1_2713 | PC1_3124 | PC1_2713 | PC1_3124 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | KEGG: eca:ECA3328 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.917 |
PC1_2713 | PC1_3454 | PC1_2713 | PC1_3454 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.907 |
PC1_2713 | apt | PC1_2713 | PC1_1075 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.923 |
PC1_2713 | gmk | PC1_2713 | PC1_4209 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.916 |
PC1_2713 | gpt | PC1_2713 | PC1_3289 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.923 |
PC1_2713 | guaA | PC1_2713 | PC1_3003 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.910 |
PC1_2713 | guaB | PC1_2713 | PC1_3004 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
PC1_2713 | guaC | PC1_2713 | PC1_3578 | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.948 |
PC1_2745 | PC1_2713 | PC1_2745 | PC1_2713 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | 0.908 |
PC1_2745 | PC1_3124 | PC1_2745 | PC1_3124 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | KEGG: eca:ECA3328 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.917 |
PC1_2745 | PC1_3454 | PC1_2745 | PC1_3454 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.907 |
PC1_2745 | apt | PC1_2745 | PC1_1075 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.923 |
PC1_2745 | gmk | PC1_2745 | PC1_4209 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.916 |
PC1_2745 | gpt | PC1_2745 | PC1_3289 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.923 |
PC1_2745 | guaA | PC1_2745 | PC1_3003 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.921 |
PC1_2745 | guaB | PC1_2745 | PC1_3004 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
PC1_2745 | guaC | PC1_2745 | PC1_3578 | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.948 |
PC1_3124 | PC1_2713 | PC1_3124 | PC1_2713 | KEGG: eca:ECA3328 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: glutamine amidotransferase class-I; KEGG: kpn:KPN_01781 glutamine amidotransferase. | 0.917 |
PC1_3124 | PC1_2745 | PC1_3124 | PC1_2745 | KEGG: eca:ECA3328 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: glutamine amidotransferase class-I; KEGG: eca:ECA3005 glutamine amidotransferase. | 0.917 |