node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_0221 | PC1_2814 | PC1_0221 | PC1_2814 | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | TIGRFAM: phosphohistidine phosphatase SixA; PFAM: Phosphoglycerate mutase; KEGG: eca:ECA3072 phosphohistidine phosphatase. | 0.553 |
PC1_0221 | PC1_3407 | PC1_0221 | PC1_3407 | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | 0.660 |
PC1_0221 | PC1_3982 | PC1_0221 | PC1_3982 | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | Uroporphyrinogen-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; KEGG: eca:ECA4190 putative uroporphyrinogen III C-methyltransferase. | 0.632 |
PC1_0221 | seqA | PC1_0221 | PC1_1211 | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.717 |
PC1_0221 | slmA | PC1_0221 | PC1_4103 | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.494 |
PC1_2814 | PC1_0221 | PC1_2814 | PC1_0221 | TIGRFAM: phosphohistidine phosphatase SixA; PFAM: Phosphoglycerate mutase; KEGG: eca:ECA3072 phosphohistidine phosphatase. | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | 0.553 |
PC1_2814 | slmA | PC1_2814 | PC1_4103 | TIGRFAM: phosphohistidine phosphatase SixA; PFAM: Phosphoglycerate mutase; KEGG: eca:ECA3072 phosphohistidine phosphatase. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.491 |
PC1_3407 | PC1_0221 | PC1_3407 | PC1_0221 | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | 0.660 |
PC1_3407 | PC1_3982 | PC1_3407 | PC1_3982 | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | Uroporphyrinogen-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; KEGG: eca:ECA4190 putative uroporphyrinogen III C-methyltransferase. | 0.541 |
PC1_3407 | seqA | PC1_3407 | PC1_1211 | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.467 |
PC1_3407 | slmA | PC1_3407 | PC1_4103 | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.436 |
PC1_3850 | slmA | PC1_3850 | PC1_4103 | PFAM: protein of unknown function UPF0270; KEGG: eca:ECA4061 hypothetical protein; Belongs to the UPF0270 family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.515 |
PC1_3982 | PC1_0221 | PC1_3982 | PC1_0221 | Uroporphyrinogen-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; KEGG: eca:ECA4190 putative uroporphyrinogen III C-methyltransferase. | PFAM: protein of unknown function DUF416; KEGG: eca:ECA0237 putative lipoprotein. | 0.632 |
PC1_3982 | PC1_3407 | PC1_3982 | PC1_3407 | Uroporphyrinogen-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; KEGG: eca:ECA4190 putative uroporphyrinogen III C-methyltransferase. | SMART: SH3 domain protein; KEGG: eca:ECA3587 putative signal transduction protein. | 0.541 |
PC1_3982 | slmA | PC1_3982 | PC1_4103 | Uroporphyrinogen-III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX; KEGG: eca:ECA4190 putative uroporphyrinogen III C-methyltransferase. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.480 |
PC1_4101 | dut | PC1_4101 | PC1_4102 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.968 |
PC1_4101 | slmA | PC1_4101 | PC1_4103 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.598 |
dut | PC1_4101 | PC1_4102 | PC1_4101 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.968 |
dut | slmA | PC1_4102 | PC1_4103 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.824 |
flhC | slmA | PC1_2614 | PC1_4103 | Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.631 |