STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMG22415.1Pentapeptide repeat-containing protein. (155 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.900
SMG23598.1
HPt (histidine-containing phosphotransfer) domain-containing protein.
  
 0.804
SMG23610.1
Diguanylate cyclase (GGDEF) domain-containing protein.
 
  
 0.774
SMG22421.1
Hypothetical protein.
       0.773
SMG35376.1
HDIG domain-containing protein.
    
 0.685
SMG26558.1
PAS domain S-box-containing protein.
  
 0.643
SMG43672.1
Pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.641
SMG23159.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.
 
  
 0.571
SMG34962.1
PAS domain S-box-containing protein.
  
 0.560
SMG23153.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.
 
  
 0.558
Your Current Organism:
Dethiosulfovibrio salsuginis
NCBI taxonomy Id: 561720
Other names: D. salsuginis, DSM 21565, Dethiosulfovibrio salsuginis Diaz-Cardenas et al. 2010, Dethiosulfovibrio sp. USBA 82, KCTC 5659, strain USBA 82
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.