STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (617 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.992
KKW93525.1
Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.979
KKW90090.1
Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.946
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.941
KKW92322.1
Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.928
KKW92323.1
Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.917
KKW90092.1
Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.902
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.893
KKW93310.1
D-amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.892
KKW90686.1
3-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.865
Your Current Organism:
Sphingobium chungbukense
NCBI taxonomy Id: 56193
Other names: IMSNU 11152, JCM 11454, KCTC 2955, Pseudomonas sp. DJ77, S. chungbukense, Sphingobium chungbukense (Kim et al. 2000) Pal et al. 2005, Sphingomonas chungbukensis, Sphingomonas chungbukensis Kim et al. 2000, Sphingomonas sp. DJ77, strain DJ77
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