STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
flhDDNA-binding transcriptional dual regulator with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)    
Predicted Functional Partners:
flhC
DNA-binding transcriptional dual regulator with FlhD; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family.
 
 0.999
ydiV
Fragment of conserved hypothetical protein (part 1); Gene remnant.
    
 
 0.946
motB
Protein that enables flagellar motor rotation; Function experimentally demonstrated in the studied species; cell process.
 
  
 0.925
fliA
RNA polymerase, sigma 28 (sigma F) factor; Function experimentally demonstrated in the studied species; factor.
 
 
 0.882
flgM
Anti-sigma factor for FliA (sigma 28); Function experimentally demonstrated in the studied species; factor.
  
  
 0.864
fliL
Flagellar biosynthesis protein; Function experimentally demonstrated in the studied species; structure.
  
   
 0.831
motA
Proton conductor component of flagella motor; Function experimentally demonstrated in the studied species; cell process.
 
    0.826
fliC
Flagellar filament structural protein (flagellin); Function experimentally demonstrated in the studied species; structure.
     
 0.820
fliD
Flagellar filament capping protein; Function experimentally demonstrated in the studied species; structure.
 
   
 0.756
ydbK
Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
   0.752
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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