STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
csrAPleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...] (61 aa)    
Predicted Functional Partners:
hfq
HF-I, host factor for RNA phage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
   
  
 0.920
barA
Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Function experimentally demonstrated in the studied species; regulator.
  
  
 0.843
uvrY
DNA-binding response regulator in two-component regulatory system with BarA; Function experimentally demonstrated in the studied species; regulator.
  
   
 0.841
ksgA
S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
     
 0.839
csrD
Inner membrane associated factor modulating specific RNAseE dependent RNA degradation pathways; Function experimentally demonstrated in the studied species; factor.
      
 0.821
rne
Fused ribonucleaseE: endoribonuclease; Function experimentally demonstrated in the studied species; enzyme.
      
 0.807
glgC
Glucose-1-phosphate adenylyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
     
 0.793
fliC
Flagellar filament structural protein (flagellin); Function experimentally demonstrated in the studied species; structure.
 
  
 0.743
arcB
Hybrid sensory histidine kinase in two-component regulatory system with ArcA; Function experimentally demonstrated in the studied species; regulator.
  
  
 0.676
evgS
Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Function experimentally demonstrated in the studied species; regulator.
  
 
 0.662
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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