STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hdfRDNA-binding transcriptional regulator; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. (279 aa)    
Predicted Functional Partners:
yeiE
Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.752
nac
DNA-binding transcriptional dual regulator of nitrogen assimilation; Function experimentally demonstrated in the studied species; regulator.
  
     0.743
aaeR
DNA-binding transcriptional regulator, efflux system; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.743
yafC
Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.717
lysR
DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator.
  
     0.703
yifE
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
   
 0.688
yhjC
Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.622
ygiP
Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.608
cbl
DNA-binding transcriptional activator of cysteine biosynthesis; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family.
  
    0.601
yeaT
Putative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.578
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.