node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
frdA | frdB | ECIAI1_4391 | ECIAI1_4390 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | 0.999 |
frdA | frdC | ECIAI1_4391 | ECIAI1_4389 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdA | frdD | ECIAI1_4391 | ECIAI1_4388 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdA | sdhA | ECIAI1_4391 | ECIAI1_0697 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Succinate dehydrogenase, flavoprotein subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.910 |
frdA | sdhB | ECIAI1_4391 | ECIAI1_0698 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Succinate dehydrogenase, FeS subunit; Function experimentally demonstrated in the studied species; carrier. | 0.997 |
frdA | sdhC | ECIAI1_4391 | ECIAI1_0695 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Function experimentally demonstrated in the studied species; membrane component. | 0.996 |
frdA | sdhD | ECIAI1_4391 | ECIAI1_0696 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH). | 0.981 |
frdA | sucC | ECIAI1_4391 | ECIAI1_0701 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.982 |
frdA | sucD | ECIAI1_4391 | ECIAI1_0702 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.972 |
frdA | yneI | ECIAI1_4391 | ECIAI1_1537 | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | Putative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.916 |
frdB | frdA | ECIAI1_4390 | ECIAI1_4391 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
frdB | frdC | ECIAI1_4390 | ECIAI1_4389 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdB | frdD | ECIAI1_4390 | ECIAI1_4388 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdB | sdhA | ECIAI1_4390 | ECIAI1_0697 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Succinate dehydrogenase, flavoprotein subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.997 |
frdB | sdhB | ECIAI1_4390 | ECIAI1_0698 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Succinate dehydrogenase, FeS subunit; Function experimentally demonstrated in the studied species; carrier. | 0.915 |
frdB | sdhC | ECIAI1_4390 | ECIAI1_0695 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Function experimentally demonstrated in the studied species; membrane component. | 0.995 |
frdB | sdhD | ECIAI1_4390 | ECIAI1_0696 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH). | 0.985 |
frdB | sucC | ECIAI1_4390 | ECIAI1_0701 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.981 |
frdB | sucD | ECIAI1_4390 | ECIAI1_0702 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.975 |
frdB | yneI | ECIAI1_4390 | ECIAI1_1537 | Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. | Putative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.907 |