node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A6R68_02715 | A6R68_03105 | A0A1A6GQZ9 | A0A1A6GQ84 | MGS domain-containing protein. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.999 |
A6R68_02715 | A6R68_03107 | A0A1A6GQZ9 | A0A1A6GPY3 | MGS domain-containing protein. | AIRC domain-containing protein. | 0.999 |
A6R68_02715 | A6R68_05331 | A0A1A6GQZ9 | A0A1A6GIP1 | MGS domain-containing protein. | Uncharacterized protein. | 0.888 |
A6R68_02715 | A6R68_05788 | A0A1A6GQZ9 | A0A1A6GIZ0 | MGS domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.987 |
A6R68_02715 | A6R68_08416 | A0A1A6GQZ9 | A0A1A6G2P5 | MGS domain-containing protein. | Uncharacterized protein. | 0.997 |
A6R68_02715 | A6R68_08789 | A0A1A6GQZ9 | A0A1A6G2Q6 | MGS domain-containing protein. | GARS_C domain-containing protein. | 0.999 |
A6R68_02715 | A6R68_18593 | A0A1A6GQZ9 | A0A1A6HL53 | MGS domain-containing protein. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.997 |
A6R68_02715 | IMPDH | A0A1A6GQZ9 | A0A1A6H0B2 | MGS domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.952 |
A6R68_02715 | IMPDH-2 | A0A1A6GQZ9 | A0A1A6H2W4 | MGS domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.952 |
A6R68_02715 | ITPA | A0A1A6GQZ9 | A0A1A6GKQ9 | MGS domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.888 |
A6R68_03105 | A6R68_02715 | A0A1A6GQ84 | A0A1A6GQZ9 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | MGS domain-containing protein. | 0.999 |
A6R68_03105 | A6R68_03107 | A0A1A6GQ84 | A0A1A6GPY3 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | AIRC domain-containing protein. | 0.999 |
A6R68_03105 | A6R68_05331 | A0A1A6GQ84 | A0A1A6GIP1 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Uncharacterized protein. | 0.600 |
A6R68_03105 | A6R68_05788 | A0A1A6GQ84 | A0A1A6GIZ0 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.963 |
A6R68_03105 | A6R68_08416 | A0A1A6GQ84 | A0A1A6G2P5 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Uncharacterized protein. | 0.985 |
A6R68_03105 | A6R68_08789 | A0A1A6GQ84 | A0A1A6G2Q6 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | GARS_C domain-containing protein. | 0.999 |
A6R68_03105 | A6R68_18593 | A0A1A6GQ84 | A0A1A6HL53 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.985 |
A6R68_03105 | IMPDH | A0A1A6GQ84 | A0A1A6H0B2 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.791 |
A6R68_03105 | IMPDH-2 | A0A1A6GQ84 | A0A1A6H2W4 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.788 |
A6R68_03105 | ITPA | A0A1A6GQ84 | A0A1A6GKQ9 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.600 |