STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACT1Actin-1. (385 aa)    
Predicted Functional Partners:
COF1
Cofilin; Belongs to the actin-binding proteins ADF family.
   
 0.971
MYH11
Myosin-11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.971
Actl6a
Actin-like protein 6A; Belongs to the actin family.
  
 
0.970
A0H81_13938
Uncharacterized protein.
    
 0.969
ACTR10
Actin-related protein 10; Belongs to the actin family.
    
0.966
PRO1B
Profilin; Belongs to the profilin family.
    
 0.966
cap2
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 0.965
arc1
Actin-related protein 2/3 complex subunit 1.
   
 0.964
ARP2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
  
 
0.964
A0H81_01898
WH1 domain-containing protein.
    
 0.964
Your Current Organism:
Grifola frondosa
NCBI taxonomy Id: 5627
Other names: G. frondosa, maitake
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.