FAD12_7 protein (Grifola frondosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FAD12_7

Delta(12) fatty acid desaturase. (264 aa)

Predicted Functional Partners:

A0H81_13327

0.876

PLA2G4A

0.590

OLE1_2

0.576

rpb2

0.576

OLE1_0

0.572

OLE1_3

0.572

OLE1_1

0.572

PEX5

0.571

rpb5

0.571

rpb7

0.571

Your Current Organism:

Grifola frondosa

NCBI taxonomy Id: 5627
Other names: G. frondosa, maitake

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0H81_13327	FAD12_7	A0A1C7LQD6	A0A1C7LSS3	Uncharacterized protein.	Delta(12) fatty acid desaturase.	0.876
A0H81_13327	OLE1_0	A0A1C7LQD6	A0A1C7LXF6	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.572
A0H81_13327	OLE1_1	A0A1C7LQD6	A0A1C7M642	Uncharacterized protein.	Acyl-CoA desaturase.	0.572
A0H81_13327	OLE1_2	A0A1C7LQD6	A0A1C7MLI9	Uncharacterized protein.	Acyl-CoA desaturase.	0.576
A0H81_13327	OLE1_3	A0A1C7LQD6	A0A1C7LXJ4	Uncharacterized protein.	Acyl-CoA desaturase.	0.572
A0H81_13327	PEX5	A0A1C7LQD6	A0A1C7LU82	Uncharacterized protein.	Peroxisomal targeting signal 1 receptor.	0.571
A0H81_13327	PLA2G4A	A0A1C7LQD6	A0A1C7M740	Uncharacterized protein.	Lysophospholipase.	0.590
A0H81_13327	rpb2	A0A1C7LQD6	A0A1C7MPY9	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.576
A0H81_13327	rpb5	A0A1C7LQD6	A0A1C7M7A8	Uncharacterized protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC1.	0.571
A0H81_13327	rpb7	A0A1C7LQD6	A0A1C7M9V9	Uncharacterized protein.	DNA-directed RNA polymerase II subunit rpb7.	0.571
FAD12_7	A0H81_13327	A0A1C7LSS3	A0A1C7LQD6	Delta(12) fatty acid desaturase.	Uncharacterized protein.	0.876
FAD12_7	OLE1_0	A0A1C7LSS3	A0A1C7LXF6	Delta(12) fatty acid desaturase.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.572
FAD12_7	OLE1_1	A0A1C7LSS3	A0A1C7M642	Delta(12) fatty acid desaturase.	Acyl-CoA desaturase.	0.572
FAD12_7	OLE1_2	A0A1C7LSS3	A0A1C7MLI9	Delta(12) fatty acid desaturase.	Acyl-CoA desaturase.	0.576
FAD12_7	OLE1_3	A0A1C7LSS3	A0A1C7LXJ4	Delta(12) fatty acid desaturase.	Acyl-CoA desaturase.	0.572
FAD12_7	PEX5	A0A1C7LSS3	A0A1C7LU82	Delta(12) fatty acid desaturase.	Peroxisomal targeting signal 1 receptor.	0.571
FAD12_7	PLA2G4A	A0A1C7LSS3	A0A1C7M740	Delta(12) fatty acid desaturase.	Lysophospholipase.	0.590
FAD12_7	rpb2	A0A1C7LSS3	A0A1C7MPY9	Delta(12) fatty acid desaturase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.576
FAD12_7	rpb5	A0A1C7LSS3	A0A1C7M7A8	Delta(12) fatty acid desaturase.	DNA-directed RNA polymerases I, II, and III subunit RPABC1.	0.571
FAD12_7	rpb7	A0A1C7LSS3	A0A1C7M9V9	Delta(12) fatty acid desaturase.	DNA-directed RNA polymerase II subunit rpb7.	0.571

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

32

PPI enrichment p-value:

6.32e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

4 of 8

2.53

2.87

3.84e-06

GO:0006790

Sulfur compound metabolic process

5 of 139

1.39

1.14

0.0016

GO:0019379

Sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

2 of 3

2.66

0.93

0.0203

GO:0070814

Hydrogen sulfide biosynthetic process

2 of 5

2.44

0.91

0.0213

GO:0042128

Nitrate assimilation

2 of 6

2.36

0.88

0.0243

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

6 of 53

1.89

2.99

1.13e-07

GO:0043546

Molybdopterin cofactor binding

3 of 4

2.71

2.47

2.83e-05

GO:0030151

Molybdenum ion binding

3 of 5

2.61

2.39

3.62e-05

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

2.83

1.13

0.0089

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9918

Mixed, incl. Nitrate metabolic process, and Sulfate assimilation

10 of 26

2.42

8.8

2.34e-20

CL:9920

Nitrate metabolic process, and O2/CO2 exchange in erythrocytes

5 of 10

2.53

4.57

1.30e-09

CL:9947

Sulfate assimilation

4 of 5

2.74

3.9

5.12e-08

CL:9923

Nitrate reductase activity, and Nitrate import

3 of 5

2.61

2.56

1.71e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

6 of 31

2.12

4.18

6.17e-10

map01100

Metabolic pathways

9 of 1782

0.54

0.4

0.0061

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1480926

O2/CO2 exchange in erythrocytes

2 of 6

2.36

0.71

0.0497

MAP-1237044

Erythrocytes take up carbon dioxide and release oxygen

2 of 6

2.36

0.71

0.0497

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0500

Molybdenum

3 of 6

2.53

2.49

2.21e-05

KW-0408

Iron

5 of 60

1.75

2.29

4.18e-06

KW-0349

Heme

3 of 24

1.93

1.63

0.00051

KW-0274

FAD

3 of 36

1.75

1.39

0.0012

KW-0560

Oxidoreductase

4 of 156

1.24

0.99

0.0022

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

4 of 8

2.53

3.15

1.07e-06

PF03404

Mo-co oxidoreductase dimerisation domain

3 of 3

2.83

2.56

2.04e-05

PF00174

Oxidoreductase molybdopterin binding domain

3 of 3

2.83

2.56

2.04e-05

PF00970

Oxidoreductase FAD-binding domain

3 of 5

2.61

2.45

2.85e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001433

Oxidoreductase FAD/NAD(P)-binding

4 of 8

2.53

2.92

3.08e-06

IPR017938

Riboflavin synthase-like beta-barrel

4 of 13

2.32

2.65

7.38e-06

IPR017927

FAD-binding domain, ferredoxin reductase-type

4 of 15

2.26

2.61

8.00e-06

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

4 of 17

2.21

2.55

9.25e-06

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

3 of 3

2.83

2.53

2.34e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 21

1.99

1.47

0.0013

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About