A0H81_03338 protein (Grifola frondosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

A0H81_03338

Uncharacterized protein. (155 aa)

Predicted Functional Partners:

Thoc1

0.981

A0H81_04055

0.974

A0H81_09701

0.972

cbc1

0.963

A0H81_04304

0.956

A0H81_01213

0.956

SUB2

0.956

A0H81_11386

0.951

cdc28

0.951

CEF1

0.939

Your Current Organism:

Grifola frondosa

NCBI taxonomy Id: 5627
Other names: G. frondosa, maitake

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0H81_01213	A0H81_03338	A0A1C7MPB3	A0A1C7MIA4	Uncharacterized protein.	Uncharacterized protein.	0.956
A0H81_01213	A0H81_04055	A0A1C7MPB3	A0A1C7MHW5	Uncharacterized protein.	Uncharacterized protein.	0.963
A0H81_01213	A0H81_09701	A0A1C7MPB3	A0A1C7M1J3	Uncharacterized protein.	Uncharacterized protein.	0.959
A0H81_01213	A0H81_11386	A0A1C7MPB3	A0A1C7LVY1	Uncharacterized protein.	Protein kinase domain-containing protein.	0.752
A0H81_01213	CEF1	A0A1C7MPB3	A0A1C7MFW6	Uncharacterized protein.	Pre-mRNA-splicing factor CEF1.	0.597
A0H81_01213	Thoc1	A0A1C7MPB3	A0A1C7LV66	Uncharacterized protein.	THO complex subunit 1.	0.962
A0H81_01213	cbc1	A0A1C7MPB3	A0A1C7M6I6	Uncharacterized protein.	Nuclear cap-binding protein subunit 1.	0.826
A0H81_01213	cdc28	A0A1C7MPB3	A0A1C7LXB7	Uncharacterized protein.	Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28.	0.752
A0H81_03338	A0H81_01213	A0A1C7MIA4	A0A1C7MPB3	Uncharacterized protein.	Uncharacterized protein.	0.956
A0H81_03338	A0H81_04055	A0A1C7MIA4	A0A1C7MHW5	Uncharacterized protein.	Uncharacterized protein.	0.974
A0H81_03338	A0H81_04304	A0A1C7MIA4	A0A1C7MHH0	Uncharacterized protein.	Uncharacterized protein.	0.956
A0H81_03338	A0H81_09701	A0A1C7MIA4	A0A1C7M1J3	Uncharacterized protein.	Uncharacterized protein.	0.972
A0H81_03338	A0H81_11386	A0A1C7MIA4	A0A1C7LVY1	Uncharacterized protein.	Protein kinase domain-containing protein.	0.951
A0H81_03338	CEF1	A0A1C7MIA4	A0A1C7MFW6	Uncharacterized protein.	Pre-mRNA-splicing factor CEF1.	0.939
A0H81_03338	SUB2	A0A1C7MIA4	A0A1C7MTP7	Uncharacterized protein.	ATP-dependent RNA helicase SUB2.	0.956
A0H81_03338	Thoc1	A0A1C7MIA4	A0A1C7LV66	Uncharacterized protein.	THO complex subunit 1.	0.981
A0H81_03338	cbc1	A0A1C7MIA4	A0A1C7M6I6	Uncharacterized protein.	Nuclear cap-binding protein subunit 1.	0.963
A0H81_03338	cdc28	A0A1C7MIA4	A0A1C7LXB7	Uncharacterized protein.	Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28.	0.951
A0H81_04055	A0H81_01213	A0A1C7MHW5	A0A1C7MPB3	Uncharacterized protein.	Uncharacterized protein.	0.963
A0H81_04055	A0H81_03338	A0A1C7MHW5	A0A1C7MIA4	Uncharacterized protein.	Uncharacterized protein.	0.974

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.914

expected number of edges:

15

PPI enrichment p-value:

6.1e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031564

Transcription antitermination

3 of 5

2.37

2.19

6.93e-05

GO:0006353

DNA-templated transcription, termination

3 of 5

2.37

2.19

6.93e-05

GO:0035999

Tetrahydrofolate interconversion

3 of 10

2.07

1.83

0.00025

GO:0000105

Histidine biosynthetic process

3 of 16

1.86

1.57

0.00059

GO:0009086

Methionine biosynthetic process

3 of 22

1.72

1.4

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004488

Methylenetetrahydrofolate dehydrogenase (NADP+) activity

3 of 3

2.59

2.04

0.00017

GO:0004477

Methenyltetrahydrofolate cyclohydrolase activity

3 of 3

2.59

2.04

0.00017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 338

0.84

0.57

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:958

Folic acid-containing compound metabolic process, and Deoxyribonucleotide biosynthetic process

4 of 18

1.94

1.85

0.00016

CL:861

Mixed, incl. Nucleoside monophosphate metabolic process, and Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

5 of 82

1.37

1.24

0.00061

CL:978

Tetrahydrofolate interconversion

2 of 5

2.19

0.88

0.0235

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

4 of 26

1.78

1.88

7.53e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0889

Transcription antitermination

3 of 3

2.59

2.31

5.08e-05

KW-0554

One-carbon metabolism

3 of 8

2.16

1.9

0.00021

KW-0486

Methionine biosynthesis

3 of 10

2.07

1.83

0.00024

KW-0511

Multifunctional enzyme

3 of 11

2.03

1.82

0.00024

KW-0658

Purine biosynthesis

3 of 15

1.89

1.65

0.00041

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

2.05

0.00016

PF00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

2.05

0.00016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020631

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

1.84

0.00040

IPR020630

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

1.84

0.00040

IPR000672

Tetrahydrofolate dehydrogenase/cyclohydrolase

3 of 3

2.59

1.84

0.00040

IPR046346

Aminoacid dehydrogenase-like, N-terminal domain superfamily

3 of 6

2.29

1.78

0.00042

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