STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (410 aa)    
Predicted Functional Partners:
Btus_1892
Cysteine desulfurase; KEGG: hor:Hore_22050 aminotransferase class V; PFAM: aminotransferase class V.
 0.993
Btus_1472
KEGG: hmo:HM1_1864 cysteine desulfurase family protein; PFAM: aminotransferase class V.
 0.967
Btus_1095
Cysteine desulfurase; KEGG: gka:GK2564 iron-sulfur cofactor synthesis; PFAM: aminotransferase class V.
 0.966
Btus_1423
Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
   
  
 0.953
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
     
 0.922
Btus_0454
PFAM: Fmu (Sun) domain protein; KEGG: adg:Adeg_1267 Fmu (Sun) domain protein.
 
    0.781
Btus_1890
Hypothetical protein.
       0.613
Btus_2464
PFAM: protein of unknown function DUF523; KEGG: sth:STH1078 hypothetical protein.
 
     0.544
rny
Metal dependent phosphohydrolase; Endoribonuclease that initiates mRNA decay.
     
 0.527
Btus_1249
TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB family; PFAM: Protein of unknown function UPF0004; Radical SAM domain protein; KEGG: bbe:BBR47_20340 hypothetical protein; SMART: Elongator protein 3/MiaB/NifB.
   
  
 0.515
Your Current Organism:
Kyrpidia tusciae
NCBI taxonomy Id: 562970
Other names: Bacillus tusciae DSM 2912, K. tusciae DSM 2912, Kyrpidia tusciae DSM 2912, Kyrpidia tusciae NBRC 15312, Kyrpidia tusciae str. DSM 2912, Kyrpidia tusciae strain DSM 2912
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