node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saut_0088 | Saut_0089 | Saut_0088 | Saut_0089 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | 0.792 |
Saut_0088 | cobD | Saut_0088 | Saut_0085 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.994 |
Saut_0088 | cobQ | Saut_0088 | Saut_0086 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.994 |
Saut_0088 | hisA | Saut_0088 | Saut_1734 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062:IPR006063; KEGG: tdn:Suden_1673 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: Q30PY1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-car [...] | 0.857 |
Saut_0088 | hisB | Saut_0088 | Saut_1149 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807:IPR020565; KEGG: tdn:Suden_1080 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Q30RM3 Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.899 |
Saut_0088 | hisD | Saut_0088 | Saut_1625 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.883 |
Saut_0088 | hisF | Saut_0088 | Saut_2150 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.891 |
Saut_0088 | hisG | Saut_0088 | Saut_0955 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.859 |
Saut_0088 | hisH | Saut_0088 | Saut_1735 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.899 |
Saut_0088 | hisI | Saut_0088 | Saut_1860 | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496:IPR008179; KEGG: tdn:Suden_1875 phosphoribosyl-AMP cyclohydrolase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Q7MAQ8 Histidine biosynthesis bifunctional protein hisIE; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.974 |
Saut_0089 | Saut_0088 | Saut_0089 | Saut_0088 | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | 0.792 |
Saut_0089 | cobD | Saut_0089 | Saut_0085 | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.792 |
Saut_0089 | cobQ | Saut_0089 | Saut_0086 | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.809 |
cobD | Saut_0088 | Saut_0085 | Saut_0088 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | 0.994 |
cobD | Saut_0089 | Saut_0085 | Saut_0089 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | 0.792 |
cobD | cobQ | Saut_0085 | Saut_0086 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.996 |
cobQ | Saut_0088 | Saut_0086 | Saut_0088 | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | 0.994 |
cobQ | Saut_0089 | Saut_0086 | Saut_0089 | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: csa:Csal_0546 homoserine kinase; PFAM: aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. | 0.809 |
cobQ | cobD | Saut_0086 | Saut_0085 | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.996 |
hisA | Saut_0088 | Saut_1734 | Saut_0088 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062:IPR006063; KEGG: tdn:Suden_1673 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: Q30PY1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-car [...] | Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: gme:Gmet_0487 L-threonine O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: O58115 328aa long hypothetical histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II. | 0.857 |