STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
thiGThiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)    
Predicted Functional Partners:
Saut_1445
Sulfur carrier protein ThiS; InterPro IPR003749:IPR010035; KEGG: tdn:Suden_0838 ThiS, thiamine-biosynthesis; PFAM: thiamineS protein; SPTR: A1HPQ7 Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
 
 
 0.991
Saut_0854
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594; KEGG: tdn:Suden_0761 UBA/ThiF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: A2TXV0 Molybdopterin biosynthesis MoeB protein; PFAM: ThiF family.
 
  
 0.946
thiI
(ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.946
Saut_1347
COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: tdn:Suden_1238 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: O67378 Uncharacterized protein aq_1366; PFAM: Thiamine monophosphate synthase/TENI.
 
 
 0.940
Saut_1052
COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: tdn:Suden_1173 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: B2UY65 Thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
 
 
 0.936
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.923
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.888
mqnC
Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
  
 
 0.850
mqnE
Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
  
 
 0.850
Saut_0206
thiamineS protein; InterPro IPR003749; KEGG: tdn:Suden_0253 thiamine S; PFAM: thiamineS protein; PFAM: ThiS family.
   
 
 0.844
Your Current Organism:
Sulfurimonas autotrophica
NCBI taxonomy Id: 563040
Other names: S. autotrophica DSM 16294, Sulfurimonas autotrophica DSM 16294, Sulfurimonas autotrophica OK10, Sulfurimonas autotrophica str. DSM 16294, Sulfurimonas autotrophica strain DSM 16294
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