node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saut_0012 | Saut_0139 | Saut_0012 | Saut_0139 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | 0.908 |
Saut_0012 | Saut_0563 | Saut_0012 | Saut_0563 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555; KEGG: tdn:Suden_1617 formyl transferase-like; PFAM: formyl transferase domain protein; SPTR: A1ZQX7 Phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. | 0.916 |
Saut_0012 | Saut_1722 | Saut_0012 | Saut_1722 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: tdn:Suden_1666 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A0ZJ41 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.908 |
Saut_0012 | Saut_2111 | Saut_0012 | Saut_2111 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.916 |
Saut_0012 | fmt | Saut_0012 | Saut_0767 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.908 |
Saut_0012 | folD | Saut_0012 | Saut_1226 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.918 |
Saut_0012 | glyA | Saut_0012 | Saut_1404 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.933 |
Saut_0012 | purT | Saut_0012 | Saut_0044 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
Saut_0139 | Saut_0012 | Saut_0139 | Saut_0012 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.908 |
Saut_0139 | Saut_0563 | Saut_0139 | Saut_0563 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555; KEGG: tdn:Suden_1617 formyl transferase-like; PFAM: formyl transferase domain protein; SPTR: A1ZQX7 Phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. | 0.909 |
Saut_0139 | Saut_1722 | Saut_0139 | Saut_1722 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: tdn:Suden_1666 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A0ZJ41 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.911 |
Saut_0139 | Saut_2111 | Saut_0139 | Saut_2111 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.911 |
Saut_0139 | fmt | Saut_0139 | Saut_0767 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.904 |
Saut_0139 | folD | Saut_0139 | Saut_1226 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.942 |
Saut_0139 | glyA | Saut_0139 | Saut_1404 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
Saut_0139 | metG | Saut_0139 | Saut_1133 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.939 |
Saut_0139 | purT | Saut_0139 | Saut_0044 | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
Saut_0563 | Saut_0012 | Saut_0563 | Saut_0012 | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555; KEGG: tdn:Suden_1617 formyl transferase-like; PFAM: formyl transferase domain protein; SPTR: A1ZQX7 Phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.916 |
Saut_0563 | Saut_0139 | Saut_0563 | Saut_0139 | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555; KEGG: tdn:Suden_1617 formyl transferase-like; PFAM: formyl transferase domain protein; SPTR: A1ZQX7 Phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. | COGs: COG0223 Methionyl-tRNA formyltransferase; KEGG: cla:Cla_1323 conserved hypothetical protein, putative formyltransferase; SPTR: A3W9N7 GCN5-related N-acetyltransferase; PFAM: Formyl transferase. | 0.909 |
Saut_0563 | Saut_1722 | Saut_0563 | Saut_1722 | COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376:IPR001555; KEGG: tdn:Suden_1617 formyl transferase-like; PFAM: formyl transferase domain protein; SPTR: A1ZQX7 Phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: tdn:Suden_1666 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A0ZJ41 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.932 |