STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Saut_2007KEGG: vap:Vapar_2240 hypothetical protein. (335 aa)    
Predicted Functional Partners:
Saut_2006
KEGG: dol:Dole_0233 hypothetical protein; PFAM: Domain of unknown function (DUF1814).
 
     0.953
Saut_2005
COGs: COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase; InterPro IPR002500; KEGG: nis:NIS_1681 phosphoadenosine phosphosulfate reductase; PFAM: phosphoadenosine phosphosulfate reductase; SPTR: A7I568 Phosphoadenosine phosphosulfate reductase; PFAM: Phosphoadenosine phosphosulfate reductase family; TIGRFAM: putative sulfurtransferase DndC.
     
 0.501
Saut_0386
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR004358:IPR019494:IPR013702:IPR013656:IPR 013767:IPR003594:IPR003661:IPR013655:IPR008207:IPR001789:I PR001610:IPR000014:IPR000700:IPR005467; KEGG: gme:Gmet_1707 PAS/PAC sensor hybrid histidine kinase; PFAM: domain of unknown function DUF1745; FIST C domain; PAS fold-4 domain protein; PAS fold domain protein; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; Hpt domain protein; response regulator receiver; SMART: response regulator receiver; histidine kinase A domain prot [...]
  
  
 0.497
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.468
Saut_1540
Hpt sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR004358:IPR008207:IPR001789:IPR003594:IPR 003661:IPR005467; KEGG: tdn:Suden_0617 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; Hpt domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: A3WN98 Sensor protein; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; H [...]
   
  
 0.453
Saut_2004
Hypothetical protein.
       0.434
Saut_1049
Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002489:IPR002932:IPR006982:IPR000583; KEGG: tdn:Suden_1176 glutamate synthase (NADPH) large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; PRIAM: Glutamate synthase (ferredoxin); SPTR: A2PA99 Glutamate synthase, large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
      
 0.429
Saut_1351
Diguanylate cyclase/phosphodiesterase; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR001633:IPR000160; KEGG: tdn:Suden_0735 diguanylate cyclase/phosphodiesterase; PFAM: EAL domain protein; GGDEF domain containing protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: A0NU37 Putative sensory box/GGDEF family protein; TIGRFAM: diguanylate cyclase; PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
   
  
 0.422
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
  
 0.419
Your Current Organism:
Sulfurimonas autotrophica
NCBI taxonomy Id: 563040
Other names: S. autotrophica DSM 16294, Sulfurimonas autotrophica DSM 16294, Sulfurimonas autotrophica OK10, Sulfurimonas autotrophica str. DSM 16294, Sulfurimonas autotrophica strain DSM 16294
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