STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hscBChaperone protein HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family. (174 aa)    
Predicted Functional Partners:
iscU
Hsc20 co-chaperone that acts with Hsc66 in IscU iron-sulfur cluster; A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Belongs to the NifU family.
  
 
 0.997
fdx
Ferredoxin 2fe-2s; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.
 
  
 0.994
hscA
Heat shock protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU (By similarity).
 
 
 0.993
ydiC
Integral membrane protein of SoxR-reducing complex; Belongs to the HesB/IscA family.
  
 
  0.946
mitF
Membrane-bound lytic murein transglycosylase F (YfhD); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 
 0.926
nfuA
Iron-sulfur cluster scaffold protein (YhgI); Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.922
dnaK
DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.875
cyaY
CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 
 0.809
grxD
Glutaredoxin 4 (YdhD); Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters.
     
 0.616
yadR
Essential respiratory protein A (YadR); Required for insertion of 4Fe-4S clusters for at least IspG.
  
 
 0.551
Your Current Organism:
Buchnera aphidicola 5A
NCBI taxonomy Id: 563178
Other names: B. aphidicola str. 5A (Acyrthosiphon pisum), Buchnera aphidicola str. 5A (Acyrthosiphon pisum), Buchnera aphidicola strain 5A (Acyrthosiphon pisum)
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