EFV45654.2 protein (Bilophila wadsworthia) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EFV45654.2

Hypothetical protein. (506 aa)

Predicted Functional Partners:

EFV45956.2

0.771

EFV44612.1

0.763

EFV44944.2

0.760

EFV43563.1

0.758

EFV43115.1

0.758

EFV44941.1

0.739

EFV44936.1

0.736

EFV43528.1

0.736

EFV46071.1

0.710

EFV45565.1

0.710

Your Current Organism:

Bilophila wadsworthia

NCBI taxonomy Id: 563192
Other names: B. wadsworthia 3_1_6, Bilophila wadsworthia 3_1_6, Bilophila wadsworthia str. 3_1_6, Bilophila wadsworthia strain 3_1_6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFV43115.1	EFV43528.1	HMPREF0179_03134	HMPREF0179_02647	Hypothetical protein.	PAS domain S-box protein.	0.999
EFV43115.1	EFV43563.1	HMPREF0179_03134	HMPREF0179_02631	Hypothetical protein.	Hypothetical protein.	0.999
EFV43115.1	EFV44612.1	HMPREF0179_03134	HMPREF0179_01513	Hypothetical protein.	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.825
EFV43115.1	EFV44936.1	HMPREF0179_03134	HMPREF0179_01231	Hypothetical protein.	PAS domain S-box protein.	0.999
EFV43115.1	EFV44941.1	HMPREF0179_03134	HMPREF0179_01236	Hypothetical protein.	PAS domain S-box protein.	0.999
EFV43115.1	EFV44944.2	HMPREF0179_03134	HMPREF0179_01239	Hypothetical protein.	PAS domain S-box protein.	0.999
EFV43115.1	EFV45565.1	HMPREF0179_03134	HMPREF0179_00594	Hypothetical protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.998
EFV43115.1	EFV45654.2	HMPREF0179_03134	HMPREF0179_00528	Hypothetical protein.	Hypothetical protein.	0.758
EFV43115.1	EFV45956.2	HMPREF0179_03134	HMPREF0179_00219	Hypothetical protein.	PAS domain S-box protein.	0.999
EFV43115.1	EFV46071.1	HMPREF0179_03134	HMPREF0179_00111	Hypothetical protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.998
EFV43528.1	EFV43115.1	HMPREF0179_02647	HMPREF0179_03134	PAS domain S-box protein.	Hypothetical protein.	0.999
EFV43528.1	EFV43563.1	HMPREF0179_02647	HMPREF0179_02631	PAS domain S-box protein.	Hypothetical protein.	0.999
EFV43528.1	EFV44612.1	HMPREF0179_02647	HMPREF0179_01513	PAS domain S-box protein.	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.777
EFV43528.1	EFV44936.1	HMPREF0179_02647	HMPREF0179_01231	PAS domain S-box protein.	PAS domain S-box protein.	0.999
EFV43528.1	EFV44941.1	HMPREF0179_02647	HMPREF0179_01236	PAS domain S-box protein.	PAS domain S-box protein.	0.999
EFV43528.1	EFV44944.2	HMPREF0179_02647	HMPREF0179_01239	PAS domain S-box protein.	PAS domain S-box protein.	0.999
EFV43528.1	EFV45565.1	HMPREF0179_02647	HMPREF0179_00594	PAS domain S-box protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.993
EFV43528.1	EFV45654.2	HMPREF0179_02647	HMPREF0179_00528	PAS domain S-box protein.	Hypothetical protein.	0.736
EFV43528.1	EFV45956.2	HMPREF0179_02647	HMPREF0179_00219	PAS domain S-box protein.	PAS domain S-box protein.	0.999
EFV43528.1	EFV46071.1	HMPREF0179_02647	HMPREF0179_00111	PAS domain S-box protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.915

expected number of edges:

13

PPI enrichment p-value:

0.00139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030198

Extracellular matrix organization

3 of 3

2.58

1.93

0.00027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008658

Penicillin binding

6 of 22

2.02

3.53

1.27e-08

GO:0005201

Extracellular matrix structural constituent

3 of 3

2.58

2.5

2.21e-05

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 5

2.19

1.08

0.0095

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

2 of 9

1.93

0.87

0.0220

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

3 of 3

2.58

2.43

2.96e-05

GO:0005615

Extracellular space

3 of 3

2.58

2.43

2.96e-05

GO:0005887

Integral component of plasma membrane

4 of 78

1.29

1.11

0.0011

GO:0071944

Cell periphery

7 of 655

0.61

0.44

0.0067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2028

Mixed, incl. Penicillin-binding protein, transpeptidase, and Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal

6 of 12

2.28

4.57

3.03e-10

CL:1996

Peptidoglycan biosynthesis, and Alanine racemase

7 of 29

1.97

4.01

2.39e-10

CL:2030

Penicillin-binding protein, transpeptidase, and Cell cycle, FtsW / RodA / SpoVE, conserved site

4 of 6

2.41

3.28

4.40e-07

CL:1986

Mixed, incl. Peptidoglycan biosynthesis, and Extracellular region

10 of 140

1.44

2.62

2.11e-11

CL:2169

Mixed, incl. Extracellular space, and Xylanase activity

3 of 20

1.76

1.34

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 42

1.74

2.79

7.49e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

4 of 98

1.2

0.69

0.0221

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 7

2.34

2.78

4.06e-06

PF03717

Penicillin-binding Protein dimerisation domain

3 of 3

2.58

2.25

6.54e-05

PF01391

Collagen triple helix repeat (20 copies)

2 of 3

2.41

1.08

0.0102

PF00912

Transglycosylase

2 of 4

2.28

1.05

0.0115

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 7

2.34

2.59

1.01e-05

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

3 of 3

2.58

2.14

0.00011

IPR005311

Penicillin-binding protein, dimerisation domain

3 of 3

2.58

2.14

0.00011

IPR012338

Beta-lactamase/transpeptidase-like

4 of 17

1.96

1.97

9.00e-05

IPR008160

Collagen triple helix repeat

2 of 2

2.58

1.12

0.0092

(more ...)

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