Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EFV44739.1Acetolactate synthase, small subunit. (163 aa)    
Predicted Functional Partners:
EFV44738.1
Acetolactate synthase, large subunit, biosynthetic type.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.998
EFV44094.1
Acetolactate synthase, large subunit, biosynthetic type.
 0.998
EFV43373.1
Acetolactate synthase I/II/III large subunit; Belongs to the TPP enzyme family.
 
 0.996
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.991
EFV45600.1
Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family.
 
 0.985
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.958
EFV43172.1
2-isopropylmalate synthase/homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.940
EFV46051.2
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 
 0.934
EFV44560.1
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 
 0.934
Your Current Organism:
Bilophila wadsworthia
NCBI taxonomy Id: 563192
Other names: B. wadsworthia 3_1_6, Bilophila wadsworthia 3_1_6, Bilophila wadsworthia str. 3_1_6, Bilophila wadsworthia strain 3_1_6
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.