EFV43777.1 protein (Bilophila wadsworthia) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

EFV43777.1

Hypothetical protein. (259 aa)

Predicted Functional Partners:

EFV45494.2

0.759

EFV43778.1

0.689

EFV44563.1

0.683

EFV45473.2

0.559

EFV44051.1

0.549

EFV44050.1

0.515

EFV43886.1

0.485

EFV45479.1

0.483

EFV43888.1

0.469

EFV45405.1

0.466

Your Current Organism:

Bilophila wadsworthia

NCBI taxonomy Id: 563192
Other names: B. wadsworthia 3_1_6, Bilophila wadsworthia 3_1_6, Bilophila wadsworthia str. 3_1_6, Bilophila wadsworthia strain 3_1_6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFV43777.1	EFV43778.1	HMPREF0179_02418	HMPREF0179_02419	Hypothetical protein.	Phosphomethylpyrimidine kinase.	0.689
EFV43777.1	EFV43886.1	HMPREF0179_02418	HMPREF0179_02302	Hypothetical protein.	Hypothetical protein.	0.485
EFV43777.1	EFV43888.1	HMPREF0179_02418	HMPREF0179_02304	Hypothetical protein.	Ferredoxin-1.	0.469
EFV43777.1	EFV44050.1	HMPREF0179_02418	HMPREF0179_02115	Hypothetical protein.	Sulfite reductase, dissimilatory-type subunit alpha.	0.515
EFV43777.1	EFV44051.1	HMPREF0179_02418	HMPREF0179_02116	Hypothetical protein.	Sulfite reductase, dissimilatory-type subunit beta.	0.549
EFV43777.1	EFV44563.1	HMPREF0179_02418	HMPREF0179_01629	Hypothetical protein.	Hypothetical protein.	0.683
EFV43777.1	EFV45405.1	HMPREF0179_02418	HMPREF0179_00770	Hypothetical protein.	Hypothetical protein.	0.466
EFV43777.1	EFV45473.2	HMPREF0179_02418	HMPREF0179_00704	Hypothetical protein.	Hypothetical protein.	0.559
EFV43777.1	EFV45479.1	HMPREF0179_02418	HMPREF0179_00710	Hypothetical protein.	Hypothetical protein.	0.483
EFV43777.1	EFV45494.2	HMPREF0179_02418	HMPREF0179_00699	Hypothetical protein.	Hypothetical protein.	0.759
EFV43778.1	EFV43777.1	HMPREF0179_02419	HMPREF0179_02418	Phosphomethylpyrimidine kinase.	Hypothetical protein.	0.689
EFV43886.1	EFV43777.1	HMPREF0179_02302	HMPREF0179_02418	Hypothetical protein.	Hypothetical protein.	0.485
EFV43886.1	EFV43888.1	HMPREF0179_02302	HMPREF0179_02304	Hypothetical protein.	Ferredoxin-1.	0.571
EFV43886.1	EFV44050.1	HMPREF0179_02302	HMPREF0179_02115	Hypothetical protein.	Sulfite reductase, dissimilatory-type subunit alpha.	0.813
EFV43886.1	EFV44051.1	HMPREF0179_02302	HMPREF0179_02116	Hypothetical protein.	Sulfite reductase, dissimilatory-type subunit beta.	0.683
EFV43886.1	EFV44563.1	HMPREF0179_02302	HMPREF0179_01629	Hypothetical protein.	Hypothetical protein.	0.578
EFV43886.1	EFV45473.2	HMPREF0179_02302	HMPREF0179_00704	Hypothetical protein.	Hypothetical protein.	0.774
EFV43886.1	EFV45494.2	HMPREF0179_02302	HMPREF0179_00699	Hypothetical protein.	Hypothetical protein.	0.640
EFV43888.1	EFV43777.1	HMPREF0179_02304	HMPREF0179_02418	Ferredoxin-1.	Hypothetical protein.	0.469
EFV43888.1	EFV43886.1	HMPREF0179_02304	HMPREF0179_02302	Ferredoxin-1.	Hypothetical protein.	0.571

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060563

Neuroepithelial cell differentiation

3 of 9

3.07

2.79

2.69e-05

GO:0040036

Regulation of fibroblast growth factor receptor signaling pathway

3 of 31

2.53

2.05

0.00036

GO:0110148

Biomineralization

3 of 49

2.33

1.79

0.00090

GO:0030433

Ubiquitin-dependent ERAD pathway

3 of 72

2.17

1.61

0.0016

GO:0036035

Osteoclast development

2 of 8

2.94

1.53

0.0032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005509

Calcium ion binding

7 of 822

1.48

2.17

3.93e-07

GO:0030145

Manganese ion binding

3 of 59

2.25

1.81

0.00076

GO:0051082

Unfolded protein binding

3 of 117

1.96

1.48

0.0022

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 927

1.18

0.68

0.0288

GO:0016301

Kinase activity

4 of 1004

1.15

0.65

0.0343

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

4 of 89

2.2

2.76

9.76e-06

GO:0005794

Golgi apparatus

5 of 1252

1.15

0.9

0.0037

GO:0005635

Nuclear envelope

3 of 296

1.55

0.89

0.0201

GO:0012505

Endomembrane system

8 of 3682

0.88

0.83

5.46e-05

GO:0005789

Endoplasmic reticulum membrane

4 of 958

1.17

0.72

0.0215

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:20628614

(2010) Promoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species.

3 of 4

3.42

3.44

2.52e-06

PMID:33199536

(2020) Mannose-Binding Lectin Possesses Agglutination Activity and Promotes Opsonophagocytosis of Macrophages with Calreticulin Interaction in an Early Vertebrate.

3 of 5

3.32

3.43

2.52e-06

PMID:28254621

(2017) Nutrigenomics and immune function in fish: new insights from omics technologies.

3 of 6

3.25

3.43

2.52e-06

PMID:24060503

(2014) Rainbow trout (Oncorhynchus mykiss) contain two calnexin genes which encode distinct proteins.

3 of 7

3.18

3.42

2.52e-06

PMID:35153391

(2022) Molecular cloning, sequence characterization, and expression analysis of C-type lectin (CTL) and ER-Golgi intermediate compartment 53-kDa protein (ERGIC-53) homologs from the freshwater prawn, Macrobrachium rosenbergii.

3 of 8

3.12

3.41

2.52e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34412

Mixed, incl. FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

4 of 11

3.11

4.65

2.11e-08

CL:39427

Calreticulin, and Protein disulphide isomerase

3 of 6

3.25

3.62

1.22e-06

CL:34416

FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

3 of 6

3.25

3.62

1.22e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04141

Protein processing in endoplasmic reticulum

3 of 179

1.77

1.38

0.0024

onl04145

Phagosome

3 of 210

1.7

1.35

0.0024

onl05168

Herpes simplex virus 1 infection

3 of 342

1.49

1.09

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000480

Scavenging by Class A Receptors

3 of 11

2.98

3.06

9.12e-06

MAP-901042

Calnexin/calreticulin cycle

3 of 33

2.5

2.6

3.85e-05

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

3 of 45

2.37

2.44

6.16e-05

MAP-8957275

Post-translational protein phosphorylation

4 of 168

1.92

2.27

3.85e-05

MAP-381426

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

4 of 199

1.85

2.15

4.99e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005788

Endoplasmic reticulum lumen

4 of 56

2.4

3.24

2.01e-06

GOCC:0012505

Endomembrane system

8 of 2410

1.07

1.21

2.27e-06

GOCC:0005794

Golgi apparatus

4 of 581

1.38

1.01

0.0062

GOCC:0005737

Cytoplasm

8 of 6894

0.61

0.44

0.0062

GOCC:0043231

Intracellular membrane-bounded organelle

8 of 7225

0.59

0.43

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

3 of 26

2.61

2.81

1.82e-05

KW-0256

Endoplasmic reticulum

3 of 108

1.99

1.79

0.00055

KW-0106

Calcium

4 of 429

1.52

1.46

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06702

Golgi casein kinase, C-terminal, Fam20

4 of 6

3.37

5.42

1.34e-09

PF00262

Calreticulin family

3 of 5

3.32

3.68

1.00e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009169

Calreticulin

3 of 3

3.55

3.53

1.84e-06

IPR024869

FAM20

3 of 5

3.32

3.43

2.57e-06

IPR018124

Calreticulin/calnexin, conserved site

3 of 5

3.32

3.43

2.57e-06

IPR009581

FAM20, C-terminal

3 of 5

3.32

3.43

2.57e-06

IPR009033

Calreticulin/calnexin, P domain superfamily

3 of 5

3.32

3.43

2.57e-06

(more ...)

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