| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFV43588.1 | EFV43723.1 | HMPREF0179_02604 | HMPREF0179_02489 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Belongs to the 5'-nucleotidase family. | 0.917 |
| EFV43588.1 | gpt | HMPREF0179_02604 | HMPREF0179_02200 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.940 |
| EFV43588.1 | guaB | HMPREF0179_02604 | HMPREF0179_03493 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.946 |
| EFV43588.1 | purA | HMPREF0179_02604 | HMPREF0179_00915 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.940 |
| EFV43588.1 | surE | HMPREF0179_02604 | HMPREF0179_02512 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
| EFV43588.1 | upp | HMPREF0179_02604 | HMPREF0179_00941 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.470 |
| EFV43723.1 | EFV43588.1 | HMPREF0179_02489 | HMPREF0179_02604 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.917 |
| EFV43723.1 | EFV45396.1 | HMPREF0179_02489 | HMPREF0179_00761 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.913 |
| EFV43723.1 | cpdA | HMPREF0179_02489 | HMPREF0179_00222 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.915 |
| EFV43723.1 | gpt | HMPREF0179_02489 | HMPREF0179_02200 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.923 |
| EFV43723.1 | guaB | HMPREF0179_02489 | HMPREF0179_03493 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.918 |
| EFV43723.1 | nadD | HMPREF0179_02489 | HMPREF0179_01064 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.917 |
| EFV43723.1 | purA | HMPREF0179_02489 | HMPREF0179_00915 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.912 |
| EFV43723.1 | surE | HMPREF0179_02489 | HMPREF0179_02512 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| EFV43723.1 | tmk | HMPREF0179_02489 | HMPREF0179_02510 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.916 |
| EFV43723.1 | upp | HMPREF0179_02489 | HMPREF0179_00941 | Hypothetical protein; Belongs to the 5'-nucleotidase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.912 |
| EFV45396.1 | EFV43723.1 | HMPREF0179_00761 | HMPREF0179_02489 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Hypothetical protein; Belongs to the 5'-nucleotidase family. | 0.913 |
| EFV45396.1 | cpdA | HMPREF0179_00761 | HMPREF0179_00222 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.906 |
| EFV45396.1 | gpt | HMPREF0179_00761 | HMPREF0179_02200 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.830 |
| EFV45396.1 | guaB | HMPREF0179_00761 | HMPREF0179_03493 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.845 |