Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
EFV43136.1Hypothetical protein. (150 aa)    
Predicted Functional Partners:
dnaK
Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.880
EFV45885.1
Hypothetical protein.
  
 
 0.856
EFV44812.1
Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 
 0.844
htpG
Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity.
   
 0.822
napA
Periplasmic nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
     
 0.783
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
  
 
 0.782
EFV43137.2
Hypothetical protein.
     
 0.778
EFV46051.2
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
   
 0.727
EFV44560.1
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
   
 0.727
groL
Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.668
Your Current Organism:
Bilophila wadsworthia
NCBI taxonomy Id: 563192
Other names: B. wadsworthia 3_1_6, Bilophila wadsworthia 3_1_6, Bilophila wadsworthia str. 3_1_6, Bilophila wadsworthia strain 3_1_6
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