node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHK01964.1 | SHK02045.1 | SAMN05216369_0030 | SAMN05216369_0034 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.974 |
SHK01964.1 | SHK02073.1 | SAMN05216369_0030 | SAMN05216369_0035 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.996 |
SHK01964.1 | SHK02957.1 | SAMN05216369_0030 | SAMN05216369_0078 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.498 |
SHK01964.1 | SHK22974.1 | SAMN05216369_0030 | SAMN05216369_1096 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
SHK01964.1 | SHK47303.1 | SAMN05216369_0030 | SAMN05216369_2209 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.770 |
SHK01964.1 | SHK85736.1 | SAMN05216369_0030 | SAMN05216369_3374 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.603 |
SHK01964.1 | folE | SAMN05216369_0030 | SAMN05216369_0756 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | GTP cyclohydrolase I. | 0.995 |
SHK02045.1 | SHK01964.1 | SAMN05216369_0034 | SAMN05216369_0030 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.974 |
SHK02045.1 | SHK02073.1 | SAMN05216369_0034 | SAMN05216369_0035 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.999 |
SHK02045.1 | SHK02957.1 | SAMN05216369_0034 | SAMN05216369_0078 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.498 |
SHK02045.1 | SHK22974.1 | SAMN05216369_0034 | SAMN05216369_1096 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
SHK02045.1 | SHK47303.1 | SAMN05216369_0034 | SAMN05216369_2209 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.668 |
SHK02045.1 | SHK85736.1 | SAMN05216369_0034 | SAMN05216369_3374 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.603 |
SHK02045.1 | folE | SAMN05216369_0034 | SAMN05216369_0756 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | GTP cyclohydrolase I. | 0.924 |
SHK02045.1 | plsY | SAMN05216369_0034 | SAMN05216369_0036 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.615 |
SHK02073.1 | SHK01964.1 | SAMN05216369_0035 | SAMN05216369_0030 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.996 |
SHK02073.1 | SHK02045.1 | SAMN05216369_0035 | SAMN05216369_0034 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.999 |
SHK02073.1 | SHK02957.1 | SAMN05216369_0035 | SAMN05216369_0078 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.556 |
SHK02073.1 | SHK18937.1 | SAMN05216369_0035 | SAMN05216369_0884 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Alkaline phosphatase D. | 0.852 |
SHK02073.1 | SHK22974.1 | SAMN05216369_0035 | SAMN05216369_1096 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.994 |