node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHK12434.1 | SHK68024.1 | SAMN05216369_0553 | SAMN05216369_2802 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ. | 0.925 |
SHK12434.1 | acpP | SAMN05216369_0553 | SAMN05216369_1923 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.680 |
SHK12434.1 | rnhA | SAMN05216369_0553 | SAMN05216369_2230 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.579 |
SHK12434.1 | rnhB | SAMN05216369_0553 | SAMN05216369_3299 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.983 |
SHK12434.1 | thyA | SAMN05216369_0553 | SAMN05216369_2886 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.872 |
SHK65528.1 | acpP | SAMN05216369_2667 | SAMN05216369_1923 | NAD-dependent formate dehydrogenase flavoprotein subunit. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.999 |
SHK65528.1 | rnhB | SAMN05216369_2667 | SAMN05216369_3299 | NAD-dependent formate dehydrogenase flavoprotein subunit. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.962 |
SHK68024.1 | SHK12434.1 | SAMN05216369_2802 | SAMN05216369_0553 | ATP-dependent DNA helicase RecQ. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.925 |
SHK68024.1 | rnhA | SAMN05216369_2802 | SAMN05216369_2230 | ATP-dependent DNA helicase RecQ. | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.528 |
SHK68024.1 | rnhB | SAMN05216369_2802 | SAMN05216369_3299 | ATP-dependent DNA helicase RecQ. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.801 |
acpP | SHK12434.1 | SAMN05216369_1923 | SAMN05216369_0553 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.680 |
acpP | SHK65528.1 | SAMN05216369_1923 | SAMN05216369_2667 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | NAD-dependent formate dehydrogenase flavoprotein subunit. | 0.999 |
acpP | fabZ | SAMN05216369_1923 | SAMN05216369_3296 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.986 |
acpP | lpxD | SAMN05216369_1923 | SAMN05216369_3295 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.968 |
acpP | rnhB | SAMN05216369_1923 | SAMN05216369_3299 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.816 |
fabZ | acpP | SAMN05216369_3296 | SAMN05216369_1923 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.986 |
fabZ | lpxA | SAMN05216369_3296 | SAMN05216369_3297 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.992 |
fabZ | lpxB | SAMN05216369_3296 | SAMN05216369_3298 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.906 |
fabZ | lpxD | SAMN05216369_3296 | SAMN05216369_3295 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.982 |
fabZ | rnhB | SAMN05216369_3296 | SAMN05216369_3299 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.810 |