node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDW07359.1 | SDX40541.1 | SAMN04488238_10128 | SAMN04488238_10832 | 5-aminolevulinate synthase. | [acyl-carrier-protein] S-malonyltransferase. | 0.679 |
SDW07359.1 | SDX41351.1 | SAMN04488238_10128 | SAMN04488238_10855 | 5-aminolevulinate synthase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.902 |
SDW08563.1 | SDW20903.1 | SAMN04488238_10156 | SAMN04488238_101372 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.959 |
SDW08563.1 | SDW53494.1 | SAMN04488238_10156 | SAMN04488238_102335 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.976 |
SDW08563.1 | SDW53584.1 | SAMN04488238_10156 | SAMN04488238_102337 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.922 |
SDW08563.1 | SDW53681.1 | SAMN04488238_10156 | SAMN04488238_102339 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.972 |
SDW08563.1 | SDX41351.1 | SAMN04488238_10156 | SAMN04488238_10855 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.985 |
SDW08563.1 | hemC | SAMN04488238_10156 | SAMN04488238_102436 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
SDW08563.1 | hemE | SAMN04488238_10156 | SAMN04488238_102435 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.945 |
SDW20903.1 | SDW08563.1 | SAMN04488238_101372 | SAMN04488238_10156 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.959 |
SDW20903.1 | SDW53494.1 | SAMN04488238_101372 | SAMN04488238_102335 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.897 |
SDW20903.1 | SDW53584.1 | SAMN04488238_101372 | SAMN04488238_102337 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.419 |
SDW20903.1 | SDW53681.1 | SAMN04488238_101372 | SAMN04488238_102339 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.714 |
SDW20903.1 | SDX41351.1 | SAMN04488238_101372 | SAMN04488238_10855 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.958 |
SDW20903.1 | hemC | SAMN04488238_101372 | SAMN04488238_102436 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
SDW20903.1 | hemE | SAMN04488238_101372 | SAMN04488238_102435 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.930 |
SDW53494.1 | SDW08563.1 | SAMN04488238_102335 | SAMN04488238_10156 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.976 |
SDW53494.1 | SDW20903.1 | SAMN04488238_102335 | SAMN04488238_101372 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.897 |
SDW53494.1 | SDW53584.1 | SAMN04488238_102335 | SAMN04488238_102337 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.905 |
SDW53494.1 | SDW53681.1 | SAMN04488238_102335 | SAMN04488238_102339 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.914 |