node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ORU96014.1 | ORV03380.1 | AWB93_23435 | AWB93_02275 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.408 |
ORU96014.1 | guaA | AWB93_23435 | AWB93_07680 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.964 |
ORU96014.1 | guaB | AWB93_23435 | AWB93_07620 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.909 |
ORU96014.1 | purA | AWB93_23435 | AWB93_04370 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.787 |
ORU96014.1 | purH | AWB93_23435 | AWB93_13975 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.484 |
ORV02420.1 | ORV03380.1 | AWB93_05070 | AWB93_02275 | Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.451 |
ORV03379.1 | ORV03380.1 | AWB93_02270 | AWB93_02275 | Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.886 |
ORV03380.1 | ORU96014.1 | AWB93_02275 | AWB93_23435 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.408 |
ORV03380.1 | ORV02420.1 | AWB93_02275 | AWB93_05070 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.451 |
ORV03380.1 | ORV03379.1 | AWB93_02275 | AWB93_02270 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.886 |
ORV03380.1 | ORV03381.1 | AWB93_02275 | AWB93_02280 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |
ORV03380.1 | guaA | AWB93_02275 | AWB93_07680 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.854 |
ORV03380.1 | guaB | AWB93_02275 | AWB93_07620 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.681 |
ORV03380.1 | purA | AWB93_02275 | AWB93_04370 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.436 |
ORV03380.1 | purH | AWB93_02275 | AWB93_13975 | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.424 |
ORV03381.1 | ORV03380.1 | AWB93_02280 | AWB93_02275 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |
guaA | ORU96014.1 | AWB93_07680 | AWB93_23435 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.964 |
guaA | ORV03380.1 | AWB93_07680 | AWB93_02275 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Magnesium transporter MgtE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.854 |
guaA | guaB | AWB93_07680 | AWB93_07620 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | purA | AWB93_07680 | AWB93_04370 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.962 |