| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GACE_0933 | GACE_0934 | GACE_0933 | GACE_0934 | Isocitrate dehydrogenase (NADP-dependent). | Glycerophosphoryl diester phosphodiesterase. | 0.608 |
| GACE_0933 | GACE_0935 | GACE_0933 | GACE_0935 | Isocitrate dehydrogenase (NADP-dependent). | NADPH-dependent F420 reductase. | 0.466 |
| GACE_0934 | GACE_0933 | GACE_0934 | GACE_0933 | Glycerophosphoryl diester phosphodiesterase. | Isocitrate dehydrogenase (NADP-dependent). | 0.608 |
| GACE_0934 | GACE_0935 | GACE_0934 | GACE_0935 | Glycerophosphoryl diester phosphodiesterase. | NADPH-dependent F420 reductase. | 0.628 |
| GACE_0935 | GACE_0933 | GACE_0935 | GACE_0933 | NADPH-dependent F420 reductase. | Isocitrate dehydrogenase (NADP-dependent). | 0.466 |
| GACE_0935 | GACE_0934 | GACE_0935 | GACE_0934 | NADPH-dependent F420 reductase. | Glycerophosphoryl diester phosphodiesterase. | 0.628 |
| GACE_0935 | GACE_1505 | GACE_0935 | GACE_1505 | NADPH-dependent F420 reductase. | F420-dependent oxidoreductase. | 0.513 |
| GACE_0935 | GACE_1860 | GACE_0935 | GACE_1860 | NADPH-dependent F420 reductase. | Hydroxymethylglutaryl-CoA reductase. | 0.576 |
| GACE_0935 | cofC | GACE_0935 | GACE_2043 | NADPH-dependent F420 reductase. | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.487 |
| GACE_0935 | cofD | GACE_0935 | GACE_1169 | NADPH-dependent F420 reductase. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.725 |
| GACE_0935 | cofE | GACE_0935 | GACE_1535 | NADPH-dependent F420 reductase. | F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. | 0.747 |
| GACE_0935 | cofG | GACE_0935 | GACE_2058 | NADPH-dependent F420 reductase. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.646 |
| GACE_0935 | mer | GACE_0935 | GACE_0389 | NADPH-dependent F420 reductase. | Methylentetrahydromethanopterin reductase; Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. | 0.694 |
| GACE_0935 | rnz | GACE_0935 | GACE_1456 | NADPH-dependent F420 reductase. | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.542 |
| GACE_1505 | GACE_0935 | GACE_1505 | GACE_0935 | F420-dependent oxidoreductase. | NADPH-dependent F420 reductase. | 0.513 |
| GACE_1505 | cofC | GACE_1505 | GACE_2043 | F420-dependent oxidoreductase. | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.406 |
| GACE_1505 | cofD | GACE_1505 | GACE_1169 | F420-dependent oxidoreductase. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.773 |
| GACE_1505 | cofE | GACE_1505 | GACE_1535 | F420-dependent oxidoreductase. | F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. | 0.784 |
| GACE_1505 | cofG | GACE_1505 | GACE_2058 | F420-dependent oxidoreductase. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.717 |
| GACE_1860 | GACE_0935 | GACE_1860 | GACE_0935 | Hydroxymethylglutaryl-CoA reductase. | NADPH-dependent F420 reductase. | 0.576 |